STITCH: interaction networks of chemicals and proteins Export

@article{citeulike:2144696, abstract = {The knowledge about interactions between proteins and small molecules is essential for the understanding of molecular and cellular functions. However, information on such interactions is widely dispersed across numerous databases and the literature. To facilitate access to this data, STITCH ( search tool for interactions of chemicals') integrates information about interactions from metabolic pathways, crystal structures, binding experiments and drug-target relationships. Inferred information from phenotypic effects, text mining and chemical structure similarity is used to predict relations between chemicals. STITCH further allows exploring the network of chemical relations, also in the context of associated binding proteins. Each proposed interaction can be traced back to the original data sources. Our database contains interaction information for over 68 000 different chemicals, including 2200 drugs, and connects them to 1.5 million genes across 373 genomes and their interactions contained in the STRING database. STITCH is available at http://stitch.embl.de/ 10.1093/nar/gkm795}, address = {European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland and Max-Delbr\"{u}ck-Centre for Molecular Medicine, Robert-R\"{o}ssle-Strasse 10, 13092 Berlin, Germany.}, author = {Kuhn, Michael and von Mering, Christian and Campillos, Monica and Jensen, Lars J. and Bork, Peer}, citeulike-article-id = {2144696}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/nar/gkm795}, citeulike-linkout-1 = {http://nar.oxfordjournals.org/content/gkm795/.abstract}, citeulike-linkout-2 = {http://nar.oxfordjournals.org/content/gkm795/.full.pdf}, citeulike-linkout-3 = {http://nar.oxfordjournals.org/cgi/content/abstract/36/suppl_1/D684}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/18084021}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=18084021}, day = {11}, doi = {10.1093/nar/gkm795}, issn = {1362-4962}, journal = {Nucl. Acids Res.}, keywords = {database, embl, interaction, stitch}, month = {January}, number = {suppl\_1}, pages = {D684--688}, posted-at = {2009-01-11 12:11:05}, priority = {2}, title = {STITCH: interaction networks of chemicals and proteins}, url = {http://dx.doi.org/10.1093/nar/gkm795}, volume = {36}, year = {2008} }

TY - JOUR ID - citeulike:2144696 L3 - citeulike-article-id:2144696 N2 - The knowledge about interactions between proteins and small molecules is essential for the understanding of molecular and cellular functions. However, information on such interactions is widely dispersed across numerous databases and the literature. To facilitate access to this data, STITCH ( search tool for interactions of chemicals') integrates information about interactions from metabolic pathways, crystal structures, binding experiments and drug-target relationships. Inferred information from phenotypic effects, text mining and chemical structure similarity is used to predict relations between chemicals. STITCH further allows exploring the network of chemical relations, also in the context of associated binding proteins. Each proposed interaction can be traced back to the original data sources. Our database contains interaction information for over 68 000 different chemicals, including 2200 drugs, and connects them to 1.5 million genes across 373 genomes and their interactions contained in the STRING database. STITCH is available at http://stitch.embl.de/ 10.1093/nar/gkm795 IS - suppl_1 JF - Nucl. Acids Res. SN - 1362-4962 AD - European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland and Max-Delbrück-Centre for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin, Germany. EP - 688 TI - STITCH: interaction networks of chemicals and proteins VL - 36 SP - D684 KW - database KW - embl KW - interaction KW - stitch AU - Kuhn, Michael AU - von Mering, Christian AU - Campillos, Monica AU - Jensen, Lars AU - Bork, Peer PY - 2008/01/11/ UR - http://dx.doi.org/10.1093/nar/gkm795 ER -