Summary: LS-SNP/PDB is a new WWW resource for genome-wide annotation of human non-synonymous (amino-acid changing) SNPs. It serves high quality protein graphics rendered with UCSF Chimera molecular visualization software. The system is kept up-to-date by an automated, high-throughput build pipeline that systematically maps human nsSNPs onto Protein Data Bank structures and annotates several biologically relevant features. Availability: LS-SNP/PDB is available at http://ls-snp.icm.jhu.edu/lssnp-pdb and via links from the Protein Data Bank (PDB) Biology and Chemistry tabs, UCSC Genome Browser Gene Details and SNP Details pages and PharmGKB Gene Variants Downloads/Cross-References pages. Contact: karchin@jhu.edu Supplementary Information: Supplementary information is available at Bioinformatics online. 10.1093/bioinformatics/btp242