Effects of multisensory stimulation in people with Huntington's disease: a randomized controlled pilot study. Export

@article{citeulike:4925360, abstract = {OBJECTIVE: To investigate whether behavioural, motor and physiological responses of individuals with Huntington's disease (HD) to a controlled multisensory environment (MSE) are effective as a therapeutic (sustained effects) or leisure (immediate effects) activity. DESIGN: Pilot study--a randomized, controlled, two-group design. SETTING: Specialist residential unit for people with mid-late stage HD. SUBJECTS: Twelve patients with HD (one subject from each group dropped out during the study after week 8 due to medical complications). INTERVENTIONS: Patients attended eight, 30-minute sessions over a four-week period, of multisensory stimulation (MSE, treatment group) or relaxation activities (control group). MAIN OUTCOME MEASURES: Between-group comparisons for changes between assessment sessions for two behavioural assessments: Rehabilitation Evaluation--Hall and Baker (REHAB), Behaviour and Mood Disturbance Scale (BMD); a motor assessment: the dyskinesia section of the St Hans Rating Scale (SHRS); physiological measures: blood pressure, heart rate and respiratory rate. Secondary measures during intervention sessions included behavioural assessment using the Interact. RESULTS: There were no significant differences found between the groups for any main outcome measures made between sessions. The MSE group showed some positive effects within-sessions, with the Interact showing significant between-group differences in immediate effects on mood (p = 0.028). There was also a significantly different change over time for within-session changes in stimulation levels (p = 0.0002) and mood (p = 0.0001) between the groups. No physiological effects were observed in relation to sessions in either group. Two MSE subjects underwent changes in medication during the study period. CONCLUSIONS: There was no therapeutic effect of MSEs over the four-week study period. MSEs appear to be more effective thanconventional relaxation techniques as a leisure activity.}, author = {Leng, T. R. and Woodward, M. J. and Stokes, M. J. and Swan, A. V. and Wareing, L. A. and Baker, R.}, citeulike-article-id = {4925360}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12617377}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12617377}, issn = {0269-2155}, journal = {Clinical rehabilitation}, keywords = {disease, huntingtons, involuntary\_contractions, multisensory\_stimulation, physical\_therapy, pilot\_study, rct, tremor}, month = {February}, number = {1}, pages = {30--41}, posted-at = {2009-06-22 19:04:58}, priority = {2}, title = {Effects of multisensory stimulation in people with Huntington's disease: a randomized controlled pilot study.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12617377}, volume = {17}, year = {2003} }

TY - JOUR ID - citeulike:4925360 L3 - citeulike-article-id:4925360 N2 - OBJECTIVE: To investigate whether behavioural, motor and physiological responses of individuals with Huntington's disease (HD) to a controlled multisensory environment (MSE) are effective as a therapeutic (sustained effects) or leisure (immediate effects) activity. DESIGN: Pilot study--a randomized, controlled, two-group design. SETTING: Specialist residential unit for people with mid-late stage HD. SUBJECTS: Twelve patients with HD (one subject from each group dropped out during the study after week 8 due to medical complications). INTERVENTIONS: Patients attended eight, 30-minute sessions over a four-week period, of multisensory stimulation (MSE, treatment group) or relaxation activities (control group). MAIN OUTCOME MEASURES: Between-group comparisons for changes between assessment sessions for two behavioural assessments: Rehabilitation Evaluation--Hall and Baker (REHAB), Behaviour and Mood Disturbance Scale (BMD); a motor assessment: the dyskinesia section of the St Hans Rating Scale (SHRS); physiological measures: blood pressure, heart rate and respiratory rate. Secondary measures during intervention sessions included behavioural assessment using the Interact. RESULTS: There were no significant differences found between the groups for any main outcome measures made between sessions. The MSE group showed some positive effects within-sessions, with the Interact showing significant between-group differences in immediate effects on mood (p = 0.028). There was also a significantly different change over time for within-session changes in stimulation levels (p = 0.0002) and mood (p = 0.0001) between the groups. No physiological effects were observed in relation to sessions in either group. Two MSE subjects underwent changes in medication during the study period. CONCLUSIONS: There was no therapeutic effect of MSEs over the four-week study period. MSEs appear to be more effective thanconventional relaxation techniques as a leisure activity. IS - 1 JF - Clinical rehabilitation SN - 0269-2155 EP - 41 TI - Effects of multisensory stimulation in people with Huntington's disease: a randomized controlled pilot study. VL - 17 SP - 30 KW - disease KW - huntingtons KW - involuntary_contractions KW - multisensory_stimulation KW - physical_therapy KW - pilot_study KW - rct KW - tremor AU - Leng, TR AU - Woodward, MJ AU - Stokes, MJ AU - Swan, AV AU - Wareing, LA AU - Baker, R PY - 2003/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/12617377 ER -