Does Anodyne Light Therapy Improve Peripheral Neuropathy in Diabetes? Export

@article{citeulike:5013693, abstract = {10.2337/dc07-1794 —The purpose of this study was to determine the efficacy of anodyne monochromatic infrared photo energy (MIRE) in-home treatments over a 90-day period to improve peripheral sensation and self-reported quality of life in individuals with diabetes. —This was a double-blind, randomized, sham-controlled clinical trail. We randomly assigned 69 individuals with diabetes and a vibration perception threshold (VPT) between 20 and 45 V to two treatment groups: active or sham treatment. Sixty patients (120 limbs) completed the study. Anodyne units were used at home every day for 40 min for 90 days. We evaluated nerve conduction velocities, VPT, Semmes-Weinstein monofilaments (SWM) (4-, 10-, 26-, and 60-g monofilaments), the Michigan Neuropathy Screening Instrument (MNSI), a 10-cm visual analog pain scale, and a neuropathy-specific quality of life instrument. We used a nested repeated-measures multiple ANOVA design. Two sites (great toe and fifth metatarsal) were tested on both the left and right feet of each patient, so two feet were nested within each patient and two sites were nested within each foot. To analyze the ordinal SWM scores, we used a nonparametric factorial analysis for longitudinal data. —There were no significant differences in measures for quality of life, MNSI, VPT, SWM, or nerve conduction velocities in active or sham treatment groups ( > 0.05). —Anodyne MIRE therapy was no more effective than sham therapy in the treatment of sensory neuropathy in individuals with diabetes.}, author = {Lavery, Lawrence A. and Murdoch, Douglas P. and Williams, Jayme and Lavery, David C.}, citeulike-article-id = {5013693}, citeulike-linkout-0 = {http://dx.doi.org/10.2337/dc07-1794}, citeulike-linkout-1 = {http://care.diabetesjournals.org/content/31/2/316.full.abstract}, citeulike-linkout-2 = {http://care.diabetesjournals.org/content/31/2/316.full.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/17977931}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=17977931}, doi = {10.2337/dc07-1794}, journal = {Diabetes Care}, keywords = {anodyne, diabetic\_peripheral\_neuropathy, dpn, intervention, light, mire, monochromatic, near-infrared, neuropathic\_pain, paresthesia\_intervention, paresthesia\_treatment, peripheral\_diabetic\_neuropathy, physical\_therapy, physiotherapy, sensation\_intervention, sensation\_treatment, sensory\_intervention, sensory\_treatment, treatment}, month = {February}, number = {2}, pages = {316--321}, posted-at = {2009-06-29 16:47:56}, priority = {2}, title = {Does Anodyne Light Therapy Improve Peripheral Neuropathy in Diabetes?}, url = {http://dx.doi.org/10.2337/dc07-1794}, volume = {31}, year = {2008} }

TY - JOUR ID - citeulike:5013693 L3 - citeulike-article-id:5013693 N2 - 10.2337/dc07-1794 —The purpose of this study was to determine the efficacy of anodyne monochromatic infrared photo energy (MIRE) in-home treatments over a 90-day period to improve peripheral sensation and self-reported quality of life in individuals with diabetes. —This was a double-blind, randomized, sham-controlled clinical trail. We randomly assigned 69 individuals with diabetes and a vibration perception threshold (VPT) between 20 and 45 V to two treatment groups: active or sham treatment. Sixty patients (120 limbs) completed the study. Anodyne units were used at home every day for 40 min for 90 days. We evaluated nerve conduction velocities, VPT, Semmes-Weinstein monofilaments (SWM) (4-, 10-, 26-, and 60-g monofilaments), the Michigan Neuropathy Screening Instrument (MNSI), a 10-cm visual analog pain scale, and a neuropathy-specific quality of life instrument. We used a nested repeated-measures multiple ANOVA design. Two sites (great toe and fifth metatarsal) were tested on both the left and right feet of each patient, so two feet were nested within each patient and two sites were nested within each foot. To analyze the ordinal SWM scores, we used a nonparametric factorial analysis for longitudinal data. —There were no significant differences in measures for quality of life, MNSI, VPT, SWM, or nerve conduction velocities in active or sham treatment groups ( > 0.05). —Anodyne MIRE therapy was no more effective than sham therapy in the treatment of sensory neuropathy in individuals with diabetes. IS - 2 JF - Diabetes Care EP - 321 TI - Does Anodyne Light Therapy Improve Peripheral Neuropathy in Diabetes? VL - 31 SP - 316 KW - anodyne KW - diabetic_peripheral_neuropathy KW - dpn KW - intervention KW - light KW - mire KW - monochromatic KW - near-infrared KW - neuropathic_pain KW - paresthesia_intervention KW - paresthesia_treatment KW - peripheral_diabetic_neuropathy KW - physical_therapy KW - physiotherapy KW - sensation_intervention KW - sensation_treatment KW - sensory_intervention KW - sensory_treatment KW - treatment AU - Lavery, Lawrence AU - Murdoch, Douglas AU - Williams, Jayme AU - Lavery, David PY - 2008/02// UR - http://dx.doi.org/10.2337/dc07-1794 ER -