Platelet GPIb-IX-V-dependent signaling Export

@article{citeulike:274982, abstract = {Summary. Although the signaling pathways related to GPIb-IX-V have not been fully elucidated, an accumulating body of evidence suggests that phospholipase C (PLC)03B32 activation, subsequent Ca++ release and oscillations constitute an essential signal transduction pathway related to GPIb-IX-V. Src family kinases are required for PLC03B32 activation, while FcR03B3-chain/Fc03B3RIIA may be dispensable for PLC03B32 activation. Although PI-3K serves to potentiate various signaling events culminating in 03B1IIb03B23 activation, PI-3K activity may be dispensable for Src-PLC03B32 activation in GPIb-IX-V-mediated signaling. Glycosphingolipid-enriched microdomains (GEMs) appear to provide platforms for the signal transduction pathway related to GIb-IX-V, as the interaction between GPIb-IX-V and Src or PLC03B32 tyrosine phosphorylation occurs exclusively in GEMs.}, address = {Department of Laboratory Medicine, University of Yamanashi, Yamanashi, Japan; Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia}, author = {Ozaki, Y. and Asazuma, N. and Suzuki-Inoue, K. and Berndt, M. C.}, citeulike-article-id = {274982}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1538-7836.2005.01379.x}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/bsc/jth/2005/00000003/00000008/art00024}, citeulike-linkout-2 = {http://www3.interscience.wiley.com/cgi-bin/abstract/118717150/ABSTRACT}, doi = {10.1111/j.1538-7836.2005.01379.x}, issn = {1538-7933}, journal = {Journal of Thrombosis and Haemostasis}, keywords = {glycoproteins, gpib, signalling}, month = {August}, number = {8}, pages = {1745--1751}, posted-at = {2009-07-10 15:31:28}, priority = {2}, publisher = {Blackwell Publishing}, title = {Platelet GPIb-IX-V-dependent signaling}, url = {http://dx.doi.org/10.1111/j.1538-7836.2005.01379.x}, volume = {3}, year = {2005} }

TY - JOUR ID - citeulike:274982 L3 - citeulike-article-id:274982 N2 - Summary. Although the signaling pathways related to GPIb-IX-V have not been fully elucidated, an accumulating body of evidence suggests that phospholipase C (PLC)03B32 activation, subsequent Ca++ release and oscillations constitute an essential signal transduction pathway related to GPIb-IX-V. Src family kinases are required for PLC03B32 activation, while FcR03B3-chain/Fc03B3RIIA may be dispensable for PLC03B32 activation. Although PI-3K serves to potentiate various signaling events culminating in 03B1IIb03B23 activation, PI-3K activity may be dispensable for Src-PLC03B32 activation in GPIb-IX-V-mediated signaling. Glycosphingolipid-enriched microdomains (GEMs) appear to provide platforms for the signal transduction pathway related to GIb-IX-V, as the interaction between GPIb-IX-V and Src or PLC03B32 tyrosine phosphorylation occurs exclusively in GEMs. IS - 8 JF - Journal of Thrombosis and Haemostasis SN - 1538-7933 AD - Department of Laboratory Medicine, University of Yamanashi, Yamanashi, Japan; Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia EP - 1751 TI - Platelet GPIb-IX-V-dependent signaling PB - Blackwell Publishing VL - 3 SP - 1745 KW - glycoproteins KW - gpib KW - signalling AU - Ozaki, Y AU - Asazuma, N AU - Suzuki-Inoue, K AU - Berndt, MC PY - 2005/08// UR - http://dx.doi.org/10.1111/j.1538-7836.2005.01379.x ER -