A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease Export

@article{citeulike:4076468, abstract = {AimsWe sought to compare the results obtained from six major platelet function tests in the assessment of the prevalence of aspirin resistance in patients with stable coronary artery disease. Methods and results201 patients with stable coronary artery disease receiving daily aspirin therapy ([\≥]80 mg) were recruited. Platelet aggregation was measured by: (i) light transmission aggregometry (LTA) after stimulation with 1.6 mM of arachidonic acid (AA), (ii) LTA after adenosine diphosphate (ADP) (5, 10, and 20 {micro}M) stimulation, (iii) whole blood aggregometry, (iv) PFA-100(R), (v) VerifyNow Aspirin(R); urinary 11-dehydro-thromboxane B2 concentrations were also measured. Eight patients (4\%, 95\% CI 0.01-0.07) were deemed resistant to aspirin by LTA and AA. The prevalence of aspirin resistance varied according to the assay used: 10.3-51.7\% for LTA using ADP as the agonist, 18.0\% for whole blood aggregometry, 59.5\% for PFA-100(R), 6.7\% for VerifyNow Aspirin(R), and finally, 22.9\% by measuring urinary 11-dehydro-thromboxane B2 concentrations. Results from these tests showed poor correlation and agreement between themselves. ConclusionPlatelet function tests are not equally effective in measuring aspirin's antiplatelet effect and correlate poorly amongst themselves. The clinical usefulness of the different assays to classify correctly patients as aspirin resistant remains undetermined. 10.1093/eurheartj/ehm226}, author = {Lordkipanidze, Marie and Pharand, Chantal and Schampaert, Erick and Turgeon, Jacques and Palisaitis, Donald A. and Diodati, Jean G.}, citeulike-article-id = {4076468}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/eurheartj/ehm226}, citeulike-linkout-1 = {http://eurheartj.oxfordjournals.org/cgi/content/abstract/28/14/1702?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=platelet+function+aspirin&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17569678}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17569678}, day = {2}, doi = {10.1093/eurheartj/ehm226}, journal = {Eur Heart J}, keywords = {adp, aggregation, arachidonate, aspirin, assay, assays, lumiaggregometry, resistance, thromboxane, verifynow, wholeblood}, month = {July}, number = {14}, pages = {1702--1708}, posted-at = {2009-08-06 10:13:32}, priority = {2}, title = {A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease}, url = {http://dx.doi.org/10.1093/eurheartj/ehm226}, volume = {28}, year = {2007} }

TY - JOUR ID - citeulike:4076468 L3 - citeulike-article-id:4076468 N2 - AimsWe sought to compare the results obtained from six major platelet function tests in the assessment of the prevalence of aspirin resistance in patients with stable coronary artery disease. Methods and results201 patients with stable coronary artery disease receiving daily aspirin therapy ([≥]80 mg) were recruited. Platelet aggregation was measured by: (i) light transmission aggregometry (LTA) after stimulation with 1.6 mM of arachidonic acid (AA), (ii) LTA after adenosine diphosphate (ADP) (5, 10, and 20 {micro}M) stimulation, (iii) whole blood aggregometry, (iv) PFA-100(R), (v) VerifyNow Aspirin(R); urinary 11-dehydro-thromboxane B2 concentrations were also measured. Eight patients (4%, 95% CI 0.01-0.07) were deemed resistant to aspirin by LTA and AA. The prevalence of aspirin resistance varied according to the assay used: 10.3-51.7% for LTA using ADP as the agonist, 18.0% for whole blood aggregometry, 59.5% for PFA-100(R), 6.7% for VerifyNow Aspirin(R), and finally, 22.9% by measuring urinary 11-dehydro-thromboxane B2 concentrations. Results from these tests showed poor correlation and agreement between themselves. ConclusionPlatelet function tests are not equally effective in measuring aspirin's antiplatelet effect and correlate poorly amongst themselves. The clinical usefulness of the different assays to classify correctly patients as aspirin resistant remains undetermined. 10.1093/eurheartj/ehm226 IS - 14 JF - Eur Heart J EP - 1708 TI - A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease VL - 28 SP - 1702 KW - adp KW - aggregation KW - arachidonate KW - aspirin KW - assay KW - assays KW - lumiaggregometry KW - resistance KW - thromboxane KW - verifynow KW - wholeblood AU - Lordkipanidze, Marie AU - Pharand, Chantal AU - Schampaert, Erick AU - Turgeon, Jacques AU - Palisaitis, Donald AU - Diodati, Jean PY - 2007/07/02/ UR - http://dx.doi.org/10.1093/eurheartj/ehm226 ER -