Increased platelet glycoprotein Ib receptor number, enhanced platelet adhesion and severe cerebral ischaemia in a patient with polycythaemia vera Export

@article{citeulike:4564594, abstract = {The present study describes severe multiplex cerebral ischaemic laesions in a male patient being diagnosed with polycythaemia vera (PV). In contrast to previous publications, unique platelet receptor pattern with normal platelet count was identified. Glycoprotein Ib receptor number on the surface of resting platelets was increased two-fold and almost three-fold in case of activated platelets compared to the controls. More over, in an <i>in vitro</i> study when whole blood was circulated both at venous and arterial shear conditions and shear rate was adjusted according to the blood viscosity, platelet aggregate/thrombus formation was characteristic on surfaces covered with purified von Willebrand factor while in case of controls the surface was covered with single platelets or platelet monolayer. Similar results with pathological findings have not been published in PV until now. Our result undersigns the necessity of antiplatelet therapy of PV patients, even at normal platelet count.}, author = {Toth, Judit and Kappelmayer, Janos and Udvardy, Miklos L. and Szanto, Timea and Szarvas, Mariann and Rejto, Laszlo and Soltesz, Pal and Udvardy, Miklos and Harsfalvi, Jolan}, citeulike-article-id = {4564594}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/09537100902878421}, doi = {10.1080/09537100902878421}, journal = {Platelets}, keywords = {adhesion, cytometry, flowcytometry, gpib, methods, receptor, receptors}, number = {4}, pages = {282--287}, posted-at = {2009-05-20 22:30:57}, priority = {2}, publisher = {Informa Healthcare}, title = {Increased platelet glycoprotein Ib receptor number, enhanced platelet adhesion and severe cerebral ischaemia in a patient with polycythaemia vera}, url = {http://dx.doi.org/10.1080/09537100902878421}, volume = {20}, year = {2009} }

TY - JOUR ID - citeulike:4564594 L3 - citeulike-article-id:4564594 N2 - The present study describes severe multiplex cerebral ischaemic laesions in a male patient being diagnosed with polycythaemia vera (PV). In contrast to previous publications, unique platelet receptor pattern with normal platelet count was identified. Glycoprotein Ib receptor number on the surface of resting platelets was increased two-fold and almost three-fold in case of activated platelets compared to the controls. More over, in an <i>in vitro</i> study when whole blood was circulated both at venous and arterial shear conditions and shear rate was adjusted according to the blood viscosity, platelet aggregate/thrombus formation was characteristic on surfaces covered with purified von Willebrand factor while in case of controls the surface was covered with single platelets or platelet monolayer. Similar results with pathological findings have not been published in PV until now. Our result undersigns the necessity of antiplatelet therapy of PV patients, even at normal platelet count. IS - 4 JF - Platelets EP - 287 TI - Increased platelet glycoprotein Ib receptor number, enhanced platelet adhesion and severe cerebral ischaemia in a patient with polycythaemia vera PB - Informa Healthcare VL - 20 SP - 282 KW - adhesion KW - cytometry KW - flowcytometry KW - gpib KW - methods KW - receptor KW - receptors AU - Toth, Judit AU - Kappelmayer, Janos AU - Udvardy, Miklos AU - Szanto, Timea AU - Szarvas, Mariann AU - Rejto, Laszlo AU - Soltesz, Pal AU - Udvardy, Miklos AU - Harsfalvi, Jolan PY - 2009/// UR - http://dx.doi.org/10.1080/09537100902878421 ER -