Comparison of platelet aggregation using light transmission and multiple electrode aggregometry in Glanzmann thrombasthenia. Export

@article{citeulike:4926163, abstract = {We examined platelet aggregation in platelet-rich plasma (PRP) and in whole blood in nine patients with Thrombasthenia Glanzmann (TG). In PRP, aggregation was measured by monitoring the changes in light absorbance that occurred in response to adenosine 5-diphosphate (ADP), collagen and ristocetin. To measure platelet aggregation in whole blood, we used multiple electrode Impedance aggregometry using the same aggregating agents. In PRP, the patient's platelets showed defective aggregation in response to ADP, collagen, epinephrine and partially to ristocetin in all patients. In whole blood, platelet aggregation in response to the same aggregating agents showed similar response and appeared to be very similar to that which occurred in PRP. Whole blood impedance aggregometry seems to give similar results to PRP light transmission aggregometry in patients with TG. Multiple electrode aggregometry (MEA) is faster and more convenient to use in these patients.}, author = {Awidi, Abdalla and Maqablah, Ahmad and Dweik, Manar and Bsoul, Nazzal and Abu-Khader, Ahmad}, citeulike-article-id = {4926163}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/09537100903006246}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19548178}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19548178}, doi = {10.1080/09537100903006246}, issn = {1369-1635}, journal = {Platelets}, keywords = {aggregation, assay, assays, comparison, cronolog, evaluation, glanzmann, platelet, platelets, review}, month = {August}, number = {5}, pages = {297--301}, posted-at = {2009-06-22 21:16:04}, priority = {5}, publisher = {Informa Healthcare}, title = {Comparison of platelet aggregation using light transmission and multiple electrode aggregometry in Glanzmann thrombasthenia.}, url = {http://dx.doi.org/10.1080/09537100903006246}, volume = {20}, year = {2009} }

TY - JOUR ID - citeulike:4926163 L3 - citeulike-article-id:4926163 N2 - We examined platelet aggregation in platelet-rich plasma (PRP) and in whole blood in nine patients with Thrombasthenia Glanzmann (TG). In PRP, aggregation was measured by monitoring the changes in light absorbance that occurred in response to adenosine 5-diphosphate (ADP), collagen and ristocetin. To measure platelet aggregation in whole blood, we used multiple electrode Impedance aggregometry using the same aggregating agents. In PRP, the patient's platelets showed defective aggregation in response to ADP, collagen, epinephrine and partially to ristocetin in all patients. In whole blood, platelet aggregation in response to the same aggregating agents showed similar response and appeared to be very similar to that which occurred in PRP. Whole blood impedance aggregometry seems to give similar results to PRP light transmission aggregometry in patients with TG. Multiple electrode aggregometry (MEA) is faster and more convenient to use in these patients. IS - 5 JF - Platelets SN - 1369-1635 EP - 301 TI - Comparison of platelet aggregation using light transmission and multiple electrode aggregometry in Glanzmann thrombasthenia. PB - Informa Healthcare VL - 20 SP - 297 KW - aggregation KW - assay KW - assays KW - comparison KW - cronolog KW - evaluation KW - glanzmann KW - platelet KW - platelets KW - review AU - Awidi, Abdalla AU - Maqablah, Ahmad AU - Dweik, Manar AU - Bsoul, Nazzal AU - Abu-Khader, Ahmad PY - 2009/08// UR - http://dx.doi.org/10.1080/09537100903006246 ER -