Increasing intakes of the long-chain omega-3 docosahexaenoic acid: effects on platelet functions and redox status in healthy men. Export

@article{citeulike:5999408, abstract = {Docosahexaenoic acid (DHA) can prevent cardiovascular events. However, few studies have addressed the effects of DHA on both platelet reactivity and redox status in healthy subjects, and dose-related studies are scarce. The main objectives of the present study were to determine the effects of increasing doses of DHA on platelets and redox status in humans. Twelve healthy male volunteers (aged 53-65 yr) were assigned to consume an intake of successively 200, 400, 800, and 1600 mg/d DHA, as the only omega-3 fatty acid, for 2 wk each dose. Blood and urine samples were collected before and after each dose of DHA and at 8 wk after arrest of supplementation. DHA was incorporated in a dose-response fashion in platelet phospholipids. After supplementation with 400 and 800 mg/d DHA, platelet reactivity was significantly decreased. Platelet vitamin E concentration increased only after 200 mg/d DHA, while p38 MAP kinase phosphorylation decreased. Urinary isoprostane was also significantly lowered after 200 mg/d DHA but was increased after 1600 mg/d. Therefore, supplementation with only 200 mg/d DHA for 2 wk induced an antioxidant effect. It is concluded that low consumption of DHA could be an effective and nonpharmacological way to protect healthy men from platelet-related cardiovascular events.}, author = {Guillot, Nicolas and Caillet, Emilie and Laville, Martine and Calzada, Catherine and Lagarde, Michel and V\'{e}ricel, Evelyne}, citeulike-article-id = {5999408}, citeulike-linkout-0 = {http://dx.doi.org/10.1096/fj.09-133421}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19443612}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19443612}, doi = {10.1096/fj.09-133421}, issn = {1530-6860}, journal = {The FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, keywords = {diet, omega3, platelet, platelets}, month = {September}, number = {9}, pages = {2909--2916}, posted-at = {2009-10-24 12:40:53}, priority = {2}, title = {Increasing intakes of the long-chain omega-3 docosahexaenoic acid: effects on platelet functions and redox status in healthy men.}, url = {http://dx.doi.org/10.1096/fj.09-133421}, volume = {23}, year = {2009} }

TY - JOUR ID - citeulike:5999408 L3 - citeulike-article-id:5999408 N2 - Docosahexaenoic acid (DHA) can prevent cardiovascular events. However, few studies have addressed the effects of DHA on both platelet reactivity and redox status in healthy subjects, and dose-related studies are scarce. The main objectives of the present study were to determine the effects of increasing doses of DHA on platelets and redox status in humans. Twelve healthy male volunteers (aged 53-65 yr) were assigned to consume an intake of successively 200, 400, 800, and 1600 mg/d DHA, as the only omega-3 fatty acid, for 2 wk each dose. Blood and urine samples were collected before and after each dose of DHA and at 8 wk after arrest of supplementation. DHA was incorporated in a dose-response fashion in platelet phospholipids. After supplementation with 400 and 800 mg/d DHA, platelet reactivity was significantly decreased. Platelet vitamin E concentration increased only after 200 mg/d DHA, while p38 MAP kinase phosphorylation decreased. Urinary isoprostane was also significantly lowered after 200 mg/d DHA but was increased after 1600 mg/d. Therefore, supplementation with only 200 mg/d DHA for 2 wk induced an antioxidant effect. It is concluded that low consumption of DHA could be an effective and nonpharmacological way to protect healthy men from platelet-related cardiovascular events. IS - 9 JF - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology SN - 1530-6860 EP - 2916 TI - Increasing intakes of the long-chain omega-3 docosahexaenoic acid: effects on platelet functions and redox status in healthy men. VL - 23 SP - 2909 KW - diet KW - omega3 KW - platelet KW - platelets AU - Guillot, Nicolas AU - Caillet, Emilie AU - Laville, Martine AU - Calzada, Catherine AU - Lagarde, Michel AU - Véricel, Evelyne PY - 2009/09// UR - http://dx.doi.org/10.1096/fj.09-133421 ER -