Top-down enhancement and suppression of the magnitude and speed of neural activity. Export

@article{citeulike:122658, abstract = {Top-down modulation underlies our ability to selectively attend to relevant stimuli and to ignore irrelevant stimuli. Theories addressing neural mechanisms of top-down modulation are driven by studies that reveal increased magnitude of neural activity in response to directed attention, but are limited by a lack of data reporting modulation of neural processing speed, as well as comparisons with a perceptual (passive view) baseline necessary to evaluate the presence of enhancement and suppression. Utilizing functional MRI (fMRI) and event-related potential recordings (ERPs), we provide converging evidence that both the magnitude of neural activity and the speed of neural processing are modulated by top-down influences. Furthermore, both enhancement and suppression occur relative to a perceptual baseline depending on task instruction. These findings reveal the fine degree of influence that goal-directed attention exerts upon activity within the visual association cortex. We further document capacity limitations in top-down enhancement corresponding with working memory performance deficits.}, author = {Gazzaley, Adam and Cooney, Jeffrey W. and McEvoy, Kevin and Knight, Robert T. and D'Esposito, Mark}, citeulike-article-id = {122658}, citeulike-linkout-0 = {http://dx.doi.org/10.1162/0898929053279522}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/mitpress/jcn/2005/00000017/00000003/art00012}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15814009}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15814009}, doi = {10.1162/0898929053279522}, issn = {0898-929X}, journal = {Journal of cognitive neuroscience}, keywords = {erps, mdesposito, modulation, rtknight}, month = {March}, number = {3}, pages = {507--517}, posted-at = {2009-11-09 05:59:00}, priority = {2}, publisher = {MIT Press}, title = {Top-down enhancement and suppression of the magnitude and speed of neural activity.}, url = {http://dx.doi.org/10.1162/0898929053279522}, volume = {17}, year = {2005} }

TY - JOUR ID - citeulike:122658 L3 - citeulike-article-id:122658 N2 - Top-down modulation underlies our ability to selectively attend to relevant stimuli and to ignore irrelevant stimuli. Theories addressing neural mechanisms of top-down modulation are driven by studies that reveal increased magnitude of neural activity in response to directed attention, but are limited by a lack of data reporting modulation of neural processing speed, as well as comparisons with a perceptual (passive view) baseline necessary to evaluate the presence of enhancement and suppression. Utilizing functional MRI (fMRI) and event-related potential recordings (ERPs), we provide converging evidence that both the magnitude of neural activity and the speed of neural processing are modulated by top-down influences. Furthermore, both enhancement and suppression occur relative to a perceptual baseline depending on task instruction. These findings reveal the fine degree of influence that goal-directed attention exerts upon activity within the visual association cortex. We further document capacity limitations in top-down enhancement corresponding with working memory performance deficits. IS - 3 JF - Journal of cognitive neuroscience SN - 0898-929X EP - 517 TI - Top-down enhancement and suppression of the magnitude and speed of neural activity. PB - MIT Press VL - 17 SP - 507 KW - erps KW - mdesposito KW - modulation KW - rtknight AU - Gazzaley, Adam AU - Cooney, Jeffrey AU - McEvoy, Kevin AU - Knight, Robert AU - D'Esposito, Mark PY - 2005/03// UR - http://dx.doi.org/10.1162/0898929053279522 ER -