Prefrontal cortex is critical for contextual processing: evidence from brain lesions Export

@article{citeulike:5936052, abstract = {We investigated the role of prefrontal cortex (PFC) in local contextual processing using a combined event-related potentials and lesion approach. Local context was defined as the occurrence of a short predictive series of visual stimuli occurring before delivery of a target event. Targets were preceded by either randomized sequences of standards or by sequences including a three-stimulus predictive sequence signalling the occurrence of a subsequent target event. PFC lesioned patients were impaired in their ability to use local contextual information. The response time for controls revealed a larger benefit for predictable targets than for random targets relative to PFC patients. PFC patients had reduced amplitude of a context-dependent positivity and failed to generate the expected P3b latency shift between predictive and non-predictive targets. These findings show that PFC patients are unable to utilize predictive local context to guide behaviour, providing evidence for a critical role of PFC in local contextual processing. 10.1093/brain/awp230}, author = {Fogelson, Noa and Shah, Mona and Scabini, Donatella and Knight, Robert T.}, citeulike-article-id = {5936052}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/brain/awp230}, citeulike-linkout-1 = {http://brain.oxfordjournals.org/content/awp230v1/.abstract}, citeulike-linkout-2 = {http://brain.oxfordjournals.org/content/awp230v1/.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19713281}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19713281}, day = {1}, doi = {10.1093/brain/awp230}, journal = {Brain}, keywords = {clinical, context-processing, prefrontal, rtknight}, month = {November}, number = {11}, pages = {3002--3010}, posted-at = {2009-11-08 16:02:53}, priority = {2}, title = {Prefrontal cortex is critical for contextual processing: evidence from brain lesions}, url = {http://dx.doi.org/10.1093/brain/awp230}, volume = {132}, year = {2009} }

TY - JOUR ID - citeulike:5936052 L3 - citeulike-article-id:5936052 N2 - We investigated the role of prefrontal cortex (PFC) in local contextual processing using a combined event-related potentials and lesion approach. Local context was defined as the occurrence of a short predictive series of visual stimuli occurring before delivery of a target event. Targets were preceded by either randomized sequences of standards or by sequences including a three-stimulus predictive sequence signalling the occurrence of a subsequent target event. PFC lesioned patients were impaired in their ability to use local contextual information. The response time for controls revealed a larger benefit for predictable targets than for random targets relative to PFC patients. PFC patients had reduced amplitude of a context-dependent positivity and failed to generate the expected P3b latency shift between predictive and non-predictive targets. These findings show that PFC patients are unable to utilize predictive local context to guide behaviour, providing evidence for a critical role of PFC in local contextual processing. 10.1093/brain/awp230 IS - 11 JF - Brain EP - 3010 TI - Prefrontal cortex is critical for contextual processing: evidence from brain lesions VL - 132 SP - 3002 KW - clinical KW - context-processing KW - prefrontal KW - rtknight AU - Fogelson, Noa AU - Shah, Mona AU - Scabini, Donatella AU - Knight, Robert PY - 2009/11/01/ UR - http://dx.doi.org/10.1093/brain/awp230 ER -