Protein folding on rugged energy landscapes: Conformational diffusion on fractal networks Export

@article{citeulike:4958487, abstract = {We employ simulations of model proteins to study folding on rugged energylandscapes. We construct ``first-passage'' networks as the system transitionsfrom unfolded to native states. The nodes and bonds in these networkscorrespond to basins and transitions between them in the energy landscape. Wefind power-laws between the folding time and number of nodes and bonds. We showthat these scalings are determined by the fractal properties of first-passagenetworks. Reliable folding is possible in systems with rugged energy landscapesbecause first passage networks have small fractal dimension.}, archivePrefix = {arXiv}, author = {Lois, Gregg and Blawzdziewicz, J. and O'Hern, Corey S.}, citeulike-article-id = {4958487}, citeulike-linkout-0 = {http://arxiv.org/abs/0906.4385}, citeulike-linkout-1 = {http://arxiv.org/pdf/0906.4385}, day = {24}, eprint = {0906.4385}, keywords = {cmn, coarse-grained, complex\_systems, first\_passage, free-energy, hp\_model, networks, protein\_dynamics, protein\_folding, proteins, reaction\_paths, transition\_path}, month = {Jun}, posted-at = {2009-06-25 16:27:33}, priority = {2}, title = {Protein folding on rugged energy landscapes: Conformational diffusion on fractal networks}, url = {http://arxiv.org/abs/0906.4385}, year = {2009} }

TY - JOUR ID - citeulike:4958487 L3 - citeulike-article-id:4958487 N2 - We employ simulations of model proteins to study folding on rugged energylandscapes. We construct ``first-passage'' networks as the system transitionsfrom unfolded to native states. The nodes and bonds in these networkscorrespond to basins and transitions between them in the energy landscape. Wefind power-laws between the folding time and number of nodes and bonds. We showthat these scalings are determined by the fractal properties of first-passagenetworks. Reliable folding is possible in systems with rugged energy landscapesbecause first passage networks have small fractal dimension. TI - Protein folding on rugged energy landscapes: Conformational diffusion on fractal networks KW - cmn KW - coarse-grained KW - complex_systems KW - first_passage KW - free-energy KW - hp_model KW - networks KW - protein_dynamics KW - protein_folding KW - proteins KW - reaction_paths KW - transition_path AU - Lois, Gregg AU - Blawzdziewicz, J AU - O'Hern, Corey PY - 2009/Jun/24/ UR - http://arxiv.org/abs/0906.4385 ER -