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A Grand Challenge for Computing: Towards Full Reactive Modeling of a Multi-Cellular Animal Export

The Bulletin of the European Association for Theoretical Computer Science, Vol. 81 (2003), pp. 226-235.

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biology devbiosim simulation

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Biological systems can be modeled beneficially as reactive systems, using languages and tools developed for the construction of man-made systems. Our long-term aim is to model a full multi-cellular animal as a reactive system —- specifically, the C. elegans nematode worm, which is complex, but very well-defined in terms of anatomy and genetics. The challenge is to construct a full, true-to-all-known-facts, 4-dimensional, fully animated model of the development and behavior of this worm (or of a comparable multi-cellular animal), which is easily extendable as new biological facts are discovered.


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