Asymmetric cell division in C. elegans: cortical polarity and spindle positioning. Export

@article{citeulike:2610655, abstract = {The one-cell Caenorhabditis elegans embryo divides asymmetrically into a larger and smaller blastomere, each with a different fate. How does such asymmetry arise? The sperm-supplied centrosome establishes an axis of polarity in the embryo that is transduced into the establishment of anterior and posterior cortical domains. These cortical domains define the polarity of the embryo, acting upstream of the PAR proteins. The PAR proteins, in turn, determine the subsequent segregation of fate determinants and the plane of cell division. We address how cortical asymmetry could be established, relying on data from C. elegans and other polarized cells, as well as from applicable models. We discuss how cortical polarity influences spindle position to accomplish an asymmetric division, presenting the current models of spindle orientation and anaphase spindle displacement. We focus on asymmetric cell division as a function of the actin and microtubule cytoskeletons, emphasizing the cell biology of polarity.}, address = {Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. cowan@mpi-cbg.de}, author = {Cowan, C. R. and Hyman, A. A.}, citeulike-article-id = {2610655}, citeulike-linkout-0 = {http://dx.doi.org/10.1146/annurev.cellbio.19.111301.113823}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15473847}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15473847}, citeulike-linkout-3 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00024475}, doi = {10.1146/annurev.cellbio.19.111301.113823}, issn = {1081-0706}, journal = {Annu Rev Cell Dev Biol}, keywords = {c\_elegans, cytokinesis, spindle}, pages = {427--453}, posted-at = {2008-10-22 15:23:35}, priority = {4}, title = {Asymmetric cell division in C. elegans: cortical polarity and spindle positioning.}, url = {http://dx.doi.org/10.1146/annurev.cellbio.19.111301.113823}, volume = {20}, year = {2004} }

TY - JOUR ID - citeulike:2610655 L3 - citeulike-article-id:2610655 N2 - The one-cell Caenorhabditis elegans embryo divides asymmetrically into a larger and smaller blastomere, each with a different fate. How does such asymmetry arise? The sperm-supplied centrosome establishes an axis of polarity in the embryo that is transduced into the establishment of anterior and posterior cortical domains. These cortical domains define the polarity of the embryo, acting upstream of the PAR proteins. The PAR proteins, in turn, determine the subsequent segregation of fate determinants and the plane of cell division. We address how cortical asymmetry could be established, relying on data from C. elegans and other polarized cells, as well as from applicable models. We discuss how cortical polarity influences spindle position to accomplish an asymmetric division, presenting the current models of spindle orientation and anaphase spindle displacement. We focus on asymmetric cell division as a function of the actin and microtubule cytoskeletons, emphasizing the cell biology of polarity. JF - Annu Rev Cell Dev Biol SN - 1081-0706 AD - Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. cowan@mpi-cbg.de EP - 453 TI - Asymmetric cell division in C. elegans: cortical polarity and spindle positioning. VL - 20 SP - 427 KW - c_elegans KW - cytokinesis KW - spindle AU - Cowan, CR AU - Hyman, AA PY - 2004/// UR - http://dx.doi.org/10.1146/annurev.cellbio.19.111301.113823 ER -