Mathematical description of synergistic interaction of hyperthermia and ionizing radiation. Export

@article{citeulike:6075155, abstract = {A simple mathematical model of simultaneous combined action of ionizing radiation and hyperthermia has been proposed. The model suggests that the synergistic interaction of ionizing radiation and hyperthermia is expected to result from the additional lethal damage arising from the interaction of sublesions induced by both agents. These sublesions are considered nonlethal after each agent taken alone. The model was applied to the quantitative analysis of the simultaneous action of hyperthermia and ionizing radiation. It predicts the dependence of synergistic interaction of the ratio of lethal events produced by every agent used, as well as the maximal value of the synergistic effect, conditions at which the maximal interactive effect can be achieved, and the dependence of synergistic effect on dose rate. The predictions of the model have been tested with four experimental data sets reported in the literature. The theory appears to be appropriate and the conclusions valid.}, author = {Petin, V. G. and Komarov, V. P.}, citeulike-article-id = {6075155}, citeulike-linkout-0 = {http://www.biomedexperts.com/Abstract.bme/9348742}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/9348742}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=9348742}, issn = {0025-5564}, journal = {Mathematical biosciences}, keywords = {gamma, heat, ionizing, model, radiation, synergy, thermoradiation}, month = {December}, number = {2}, pages = {115--130}, posted-at = {2009-11-05 16:30:46}, priority = {3}, title = {Mathematical description of synergistic interaction of hyperthermia and ionizing radiation.}, url = {http://www.biomedexperts.com/Abstract.bme/9348742}, volume = {146}, year = {1997} }

TY - JOUR ID - citeulike:6075155 L3 - citeulike-article-id:6075155 N2 - A simple mathematical model of simultaneous combined action of ionizing radiation and hyperthermia has been proposed. The model suggests that the synergistic interaction of ionizing radiation and hyperthermia is expected to result from the additional lethal damage arising from the interaction of sublesions induced by both agents. These sublesions are considered nonlethal after each agent taken alone. The model was applied to the quantitative analysis of the simultaneous action of hyperthermia and ionizing radiation. It predicts the dependence of synergistic interaction of the ratio of lethal events produced by every agent used, as well as the maximal value of the synergistic effect, conditions at which the maximal interactive effect can be achieved, and the dependence of synergistic effect on dose rate. The predictions of the model have been tested with four experimental data sets reported in the literature. The theory appears to be appropriate and the conclusions valid. IS - 2 JF - Mathematical biosciences SN - 0025-5564 EP - 130 TI - Mathematical description of synergistic interaction of hyperthermia and ionizing radiation. VL - 146 SP - 115 KW - gamma KW - heat KW - ionizing KW - model KW - radiation KW - synergy KW - thermoradiation AU - Petin, VG AU - Komarov, VP PY - 1997/12// UR - http://www.biomedexperts.com/Abstract.bme/9348742 ER -