Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes Export

@article{citeulike:5191123, abstract = {Analysis of Neandertal DNA holds great potential for investigating the population history of this group of hominins, but progress has been limited due to the rarity of samples and damaged state of the DNA. We present a method of targeted ancient DNA sequence retrieval that greatly reduces sample destruction and sequencing demands and use this method to reconstruct the complete mitochondrial DNA (mtDNA) genomes of five Neandertals from across their geographic range. We find that mtDNA genetic diversity in Neandertals that lived 38,000 to 70,000 years ago was approximately one-third of that in contemporary modern humans. Together with analyses of mtDNA protein evolution, these data suggest that the long-term effective population size of Neandertals was smaller than that of modern humans and extant great apes. 10.1126/science.1174462}, author = {Briggs, Adrian W. and Good, Jeffrey M. and Green, Richard E. and Krause, Johannes and Maricic, Tomislav and Stenzel, Udo and Lalueza-Fox, Carles and Rudan, Pavao and Brajkovic, Dejana and Kucan, Zeljko and Gusic, Ivan and Schmitz, Ralf and Doronichev, Vladimir B. and Golovanova, Liubov V. and de La Rasilla, Marco and Fortea, Javier and Rosas, Antonio and Paabo, Svante}, citeulike-article-id = {5191123}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1174462}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5938/318}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19608918}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19608918}, day = {17}, doi = {10.1126/science.1174462}, issn = {1095-9203}, journal = {Science}, keywords = {200907, genetique, neandertalien, paleobiochimie}, month = {July}, number = {5938}, pages = {318--321}, posted-at = {2009-07-17 10:55:19}, priority = {2}, title = {Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes}, url = {http://dx.doi.org/10.1126/science.1174462}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5191123 L3 - citeulike-article-id:5191123 N2 - Analysis of Neandertal DNA holds great potential for investigating the population history of this group of hominins, but progress has been limited due to the rarity of samples and damaged state of the DNA. We present a method of targeted ancient DNA sequence retrieval that greatly reduces sample destruction and sequencing demands and use this method to reconstruct the complete mitochondrial DNA (mtDNA) genomes of five Neandertals from across their geographic range. We find that mtDNA genetic diversity in Neandertals that lived 38,000 to 70,000 years ago was approximately one-third of that in contemporary modern humans. Together with analyses of mtDNA protein evolution, these data suggest that the long-term effective population size of Neandertals was smaller than that of modern humans and extant great apes. 10.1126/science.1174462 IS - 5938 JF - Science SN - 1095-9203 EP - 321 TI - Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes VL - 325 SP - 318 KW - 200907 KW - genetique KW - neandertalien KW - paleobiochimie AU - Briggs, Adrian AU - Good, Jeffrey AU - Green, Richard AU - Krause, Johannes AU - Maricic, Tomislav AU - Stenzel, Udo AU - Lalueza-Fox, Carles AU - Rudan, Pavao AU - Brajkovic, Dejana AU - Kucan, Zeljko AU - Gusic, Ivan AU - Schmitz, Ralf AU - Doronichev, Vladimir AU - Golovanova, Liubov AU - de La Rasilla, Marco AU - Fortea, Javier AU - Rosas, Antonio AU - Paabo, Svante PY - 2009/07/17/ UR - http://dx.doi.org/10.1126/science.1174462 ER -