Ovarian Hormone Status and Abdominal Visceral Adipose Tissue Metabolism Export

@article{citeulike:1321964, abstract = {We examined abdominal sc and visceral adipose tissue metabolism in a sample of 19 regularly cycling premenopausal women (age 46.3 {+/-} 3.7 yr) and 10 women with natural menopause or pharmacological ovarian suppression (age 51.1 {+/-} 9.2 yr). Subcutaneous and visceral (omental, epiploic) adipose tissue biopsies were obtained during abdominal hysterectomies. Body composition and adipose tissue distribution were measured before the surgery by dual x-ray absorptiometry and computed tomography, respectively. Ovarian hormone-deficient women tended to be older (P = 0.08) and were characterized by increased visceral adipose tissue area (P < 0.05). Subcutaneous adipocyte size, lipoprotein lipase (LPL) activity, and basal lipolysis were not significantly different between groups. On the other hand, omental fat cell size was significantly higher in ovarian hormone-deficient women, compared with premenopausal women (P < 0.05). The omental/sc LPL activity ratio and omental adipocyte basal lipolysis were also significantly higher in ovarian hormone-deficient women (P < 0.05 for both comparisons). Significant positive correlations were found between visceral adipose tissue area and omental LPL activity (r = 0.54, P < 0.003), omental adipocyte basal lipolysis (r = 0.66, P < 0.0001), and omental fat cell size (r = 0.81, P < 0.0001). In multivariate analyses, ovarian status was no longer a significant predictor of adipose cell metabolism variables after visceral adipose tissue area was entered into the model, with the exception of the omental/sc LPL activity ratio, which remained independently associated with ovarian status. In conclusion, although the size of the visceral adipose tissue compartment was an important determinant of adipocyte metabolism in this depot, the increased omental/sc LPL activity ratio in ovarian hormone-deficient women supports the notion of a predominant visceral fat storage in these women. 10.1210/jc.2003-031561}, author = {Tchernof, Andre and Desmeules, Annie and Richard, Christian and Laberge, Philippe and Daris, Marleen and Mailloux, Jacques and Rheaume, Caroline and Dupont, Pierre}, citeulike-article-id = {1321964}, citeulike-linkout-0 = {http://dx.doi.org/10.1210/jc.2003-031561}, citeulike-linkout-1 = {http://jcem.endojournals.org/cgi/content/abstract/89/7/3425}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15240626}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15240626}, day = {1}, doi = {10.1210/jc.2003-031561}, journal = {J Clin Endocrinol Metab}, keywords = {abdominal, adipose, estrogen, lipolysis, lpl, metabolic, obesity}, month = {July}, number = {7}, pages = {3425--3430}, posted-at = {2007-05-23 18:13:03}, priority = {2}, title = {Ovarian Hormone Status and Abdominal Visceral Adipose Tissue Metabolism}, url = {http://dx.doi.org/10.1210/jc.2003-031561}, volume = {89}, year = {2004} }

TY - JOUR ID - citeulike:1321964 L3 - citeulike-article-id:1321964 N2 - We examined abdominal sc and visceral adipose tissue metabolism in a sample of 19 regularly cycling premenopausal women (age 46.3 {+/-} 3.7 yr) and 10 women with natural menopause or pharmacological ovarian suppression (age 51.1 {+/-} 9.2 yr). Subcutaneous and visceral (omental, epiploic) adipose tissue biopsies were obtained during abdominal hysterectomies. Body composition and adipose tissue distribution were measured before the surgery by dual x-ray absorptiometry and computed tomography, respectively. Ovarian hormone-deficient women tended to be older (P = 0.08) and were characterized by increased visceral adipose tissue area (P < 0.05). Subcutaneous adipocyte size, lipoprotein lipase (LPL) activity, and basal lipolysis were not significantly different between groups. On the other hand, omental fat cell size was significantly higher in ovarian hormone-deficient women, compared with premenopausal women (P < 0.05). The omental/sc LPL activity ratio and omental adipocyte basal lipolysis were also significantly higher in ovarian hormone-deficient women (P < 0.05 for both comparisons). Significant positive correlations were found between visceral adipose tissue area and omental LPL activity (r = 0.54, P < 0.003), omental adipocyte basal lipolysis (r = 0.66, P < 0.0001), and omental fat cell size (r = 0.81, P < 0.0001). In multivariate analyses, ovarian status was no longer a significant predictor of adipose cell metabolism variables after visceral adipose tissue area was entered into the model, with the exception of the omental/sc LPL activity ratio, which remained independently associated with ovarian status. In conclusion, although the size of the visceral adipose tissue compartment was an important determinant of adipocyte metabolism in this depot, the increased omental/sc LPL activity ratio in ovarian hormone-deficient women supports the notion of a predominant visceral fat storage in these women. 10.1210/jc.2003-031561 IS - 7 JF - J Clin Endocrinol Metab EP - 3430 TI - Ovarian Hormone Status and Abdominal Visceral Adipose Tissue Metabolism VL - 89 SP - 3425 KW - abdominal KW - adipose KW - estrogen KW - lipolysis KW - lpl KW - metabolic KW - obesity AU - Tchernof, Andre AU - Desmeules, Annie AU - Richard, Christian AU - Laberge, Philippe AU - Daris, Marleen AU - Mailloux, Jacques AU - Rheaume, Caroline AU - Dupont, Pierre PY - 2004/07/01/ UR - http://dx.doi.org/10.1210/jc.2003-031561 ER -