Aromatase-Deficient (ArKO) Mice Have Reduced Blood Pressure and Baroreflex Sensitivity Export

@article{citeulike:1321980, abstract = {Aromatase-deficient (ArKO) mice are deficient in estrogens due to deletion of the aromatase gene. We hypothesized that there may be changes in the cardiovascular system of ArKO mice because of evidence linking estrogens with improved cardiovascular outcomes and the induction of the glucocorticoid-metabolizing enzyme, 11{beta}-hydroxysteroid dehydrogenase type 2 (11{beta}HSD2), gene in the kidney, which is important for the regulation of blood pressure (BP). BP and baroreflex sensitivity (BRS) in female conscious ArKO mice were compared with those in age- and weight-matched wild-type (WT) mice. Power spectral analysis was used to determine cardiovascular variability and BRS. Although systolic BP was similar in the two groups, diastolic and mean BPs were lower in the ArKO mice (-6.3 {+/-} 1.9 and -4.6 {+/-} 2.1 mm Hg, respectively). Heart rate (HR) was greater in the ArKO mice (+36 {+/-} 6 beats/min). The mean BP in WT mice was 105 mm Hg, and the HR was 481 beats/min. In the autonomic frequency range, BP variability was 74\% greater, and HR variability was only 26\% that in WT mice. The BRS of ArKO mice was 46\% of the value observed in WT mice. 11{beta}HSD2 levels were unaltered in ArKO mice, except in the kidney, where they were only 10\% of WT levels. Estradiol administration to ArKO mice restored renal 11{beta}HSD2 to WT levels. The results show that ArKO mice have lower diastolic BP, but increased BP variability, perhaps due to an impaired BRS. Thus, aromatase activity is critical for normal autonomic control of the heart and, hence, for reducing the deleterious effects of high BP variability. 10.1210/en.2004-0421}, author = {Head, Geoffrey A. and Obeyesekere, Varuni R. and Jones, Margaret E. and Simpson, Evan R. and Krozowski, Zygmunt S.}, citeulike-article-id = {1321980}, citeulike-linkout-0 = {http://dx.doi.org/10.1210/en.2004-0421}, citeulike-linkout-1 = {http://endo.endojournals.org/cgi/content/abstract/145/9/4286}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15178650}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15178650}, day = {1}, doi = {10.1210/en.2004-0421}, journal = {Endocrinology}, keywords = {arko, aromatase, bp, knockout, mouse}, month = {September}, number = {9}, pages = {4286--4291}, posted-at = {2007-05-23 18:18:01}, priority = {2}, title = {Aromatase-Deficient (ArKO) Mice Have Reduced Blood Pressure and Baroreflex Sensitivity}, url = {http://dx.doi.org/10.1210/en.2004-0421}, volume = {145}, year = {2004} }

TY - JOUR ID - citeulike:1321980 L3 - citeulike-article-id:1321980 N2 - Aromatase-deficient (ArKO) mice are deficient in estrogens due to deletion of the aromatase gene. We hypothesized that there may be changes in the cardiovascular system of ArKO mice because of evidence linking estrogens with improved cardiovascular outcomes and the induction of the glucocorticoid-metabolizing enzyme, 11{beta}-hydroxysteroid dehydrogenase type 2 (11{beta}HSD2), gene in the kidney, which is important for the regulation of blood pressure (BP). BP and baroreflex sensitivity (BRS) in female conscious ArKO mice were compared with those in age- and weight-matched wild-type (WT) mice. Power spectral analysis was used to determine cardiovascular variability and BRS. Although systolic BP was similar in the two groups, diastolic and mean BPs were lower in the ArKO mice (-6.3 {+/-} 1.9 and -4.6 {+/-} 2.1 mm Hg, respectively). Heart rate (HR) was greater in the ArKO mice (+36 {+/-} 6 beats/min). The mean BP in WT mice was 105 mm Hg, and the HR was 481 beats/min. In the autonomic frequency range, BP variability was 74% greater, and HR variability was only 26% that in WT mice. The BRS of ArKO mice was 46% of the value observed in WT mice. 11{beta}HSD2 levels were unaltered in ArKO mice, except in the kidney, where they were only 10% of WT levels. Estradiol administration to ArKO mice restored renal 11{beta}HSD2 to WT levels. The results show that ArKO mice have lower diastolic BP, but increased BP variability, perhaps due to an impaired BRS. Thus, aromatase activity is critical for normal autonomic control of the heart and, hence, for reducing the deleterious effects of high BP variability. 10.1210/en.2004-0421 IS - 9 JF - Endocrinology EP - 4291 TI - Aromatase-Deficient (ArKO) Mice Have Reduced Blood Pressure and Baroreflex Sensitivity VL - 145 SP - 4286 KW - arko KW - aromatase KW - bp KW - knockout KW - mouse AU - Head, Geoffrey AU - Obeyesekere, Varuni AU - Jones, Margaret AU - Simpson, Evan AU - Krozowski, Zygmunt PY - 2004/09/01/ UR - http://dx.doi.org/10.1210/en.2004-0421 ER -