Comparable amounts of sex steroids are made outside the gonads in men and women: Strong lesson for hormone therapy of prostate and breast cancer. Export

@article{citeulike:4221950, abstract = {The objective of this study was comparison of circulating androgens and their metabolites as well as estrogens measured for the first time by a validated mass spectrometry technology in 60-80-year-old men and women of comparable age. Castration in men (n=34) reduces the total androgen pool by only about 60\% as indicated by the decrease in the serum levels of the glucuronide metabolites of androgens compared to intact men (n=1302). Such data are in agreement with the 50 to 75\% decrease in intraprostatic dihydrotestosterone (DHT) concentration after castration. Most interestingly, the same amounts of androgens and estrogens are found in postmenopausal women (n=369) and castrated men of comparable age. The most significant therapeutic implication of these findings is the absolute need to add a pure (nonsteroidal) antiandrogen to castration in men with prostate cancer in order to block the action of the 25 to 50\% DHT left in the prostate after castration. Not adding an antiandrogen to castration in men treated for prostate cancer is equivalent to not prescribing a blocker of estrogens in women suffering from breast cancer because they are postmenopausal and have low circulating estradiol.}, author = {Labrie, F. and Cusan, L. and Gomez, J. L. and Martel, C. and B\'{e}rub\'{e}, R. and B\'{e}langer, P. and B\'{e}langer, A. and Vandenput, L. and Mellstr\"{o}m, D. and Ohlsson, C.}, citeulike-article-id = {4221950}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jsbmb.2008.11.004}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19073258}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19073258}, doi = {10.1016/j.jsbmb.2008.11.004}, issn = {0960-0760}, journal = {The Journal of steroid biochemistry and molecular biology}, keywords = {androgens, breast, estrogens, gcms, hormone, prostate, sex}, month = {January}, number = {1-2}, pages = {52--56}, posted-at = {2009-03-26 11:33:15}, priority = {2}, title = {Comparable amounts of sex steroids are made outside the gonads in men and women: Strong lesson for hormone therapy of prostate and breast cancer.}, url = {http://dx.doi.org/10.1016/j.jsbmb.2008.11.004}, volume = {113}, year = {2009} }

TY - JOUR ID - citeulike:4221950 L3 - citeulike-article-id:4221950 N2 - The objective of this study was comparison of circulating androgens and their metabolites as well as estrogens measured for the first time by a validated mass spectrometry technology in 60-80-year-old men and women of comparable age. Castration in men (n=34) reduces the total androgen pool by only about 60% as indicated by the decrease in the serum levels of the glucuronide metabolites of androgens compared to intact men (n=1302). Such data are in agreement with the 50 to 75% decrease in intraprostatic dihydrotestosterone (DHT) concentration after castration. Most interestingly, the same amounts of androgens and estrogens are found in postmenopausal women (n=369) and castrated men of comparable age. The most significant therapeutic implication of these findings is the absolute need to add a pure (nonsteroidal) antiandrogen to castration in men with prostate cancer in order to block the action of the 25 to 50% DHT left in the prostate after castration. Not adding an antiandrogen to castration in men treated for prostate cancer is equivalent to not prescribing a blocker of estrogens in women suffering from breast cancer because they are postmenopausal and have low circulating estradiol. IS - 1-2 JF - The Journal of steroid biochemistry and molecular biology SN - 0960-0760 EP - 56 TI - Comparable amounts of sex steroids are made outside the gonads in men and women: Strong lesson for hormone therapy of prostate and breast cancer. VL - 113 SP - 52 KW - androgens KW - breast KW - estrogens KW - gcms KW - hormone KW - prostate KW - sex AU - Labrie, F AU - Cusan, L AU - Gomez, JL AU - Martel, C AU - Bérubé, R AU - Bélanger, P AU - Bélanger, A AU - Vandenput, L AU - Mellström, D AU - Ohlsson, C PY - 2009/01// UR - http://dx.doi.org/10.1016/j.jsbmb.2008.11.004 ER -