Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor Export

@article{citeulike:4402832, abstract = {Estrogens are generated mainly by the action of aromatase, which converts testosterone to estradiol and androstenedione to estrone. However, in addition to estradiol and estrone, a variety of other steroids, whose synthesis is not dependent on aromatase, can stimulate the estrogen receptor. Here we show that testosterone is converted into such estrogenic steroids by aromatase-negative HeLa cells. This aromatase-independent generation of estrogenic steroids is seen in aromatase-positive MCF-7 cells as well. In both cell lines, the synthesis of estrogenic steroids was blocked by inhibition of testosterone conversion into dihydrotestosterone using a 5α-reductase inhibitor finasteride, suggesting that they are generated downstream of dihydrotestosterone. This finding raises the possibility that the combination of a 5α-reductase inhibitor and an aromatase inhibitor may reduce estrogenic steroids in vivo more completely than an aromatase inhibitor alone.}, author = {Ishikawa, T. and Glidewellkenney, C. and Jameson, J.}, citeulike-article-id = {4402832}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jsbmb.2005.09.004}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0960076005004528}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16386416}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16386416}, doi = {10.1016/j.jsbmb.2005.09.004}, issn = {09600760}, journal = {The Journal of Steroid Biochemistry and Molecular Biology}, keywords = {5ar, aromatase, enzyme, estrogens, testosterone}, month = {February}, number = {2-3}, pages = {133--138}, posted-at = {2009-04-25 11:55:27}, priority = {2}, title = {Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor}, url = {http://dx.doi.org/10.1016/j.jsbmb.2005.09.004}, volume = {98}, year = {2006} }

TY - JOUR ID - citeulike:4402832 L3 - citeulike-article-id:4402832 N2 - Estrogens are generated mainly by the action of aromatase, which converts testosterone to estradiol and androstenedione to estrone. However, in addition to estradiol and estrone, a variety of other steroids, whose synthesis is not dependent on aromatase, can stimulate the estrogen receptor. Here we show that testosterone is converted into such estrogenic steroids by aromatase-negative HeLa cells. This aromatase-independent generation of estrogenic steroids is seen in aromatase-positive MCF-7 cells as well. In both cell lines, the synthesis of estrogenic steroids was blocked by inhibition of testosterone conversion into dihydrotestosterone using a 5α-reductase inhibitor finasteride, suggesting that they are generated downstream of dihydrotestosterone. This finding raises the possibility that the combination of a 5α-reductase inhibitor and an aromatase inhibitor may reduce estrogenic steroids in vivo more completely than an aromatase inhibitor alone. IS - 2-3 JF - The Journal of Steroid Biochemistry and Molecular Biology SN - 09600760 EP - 138 TI - Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor VL - 98 SP - 133 KW - 5ar KW - aromatase KW - enzyme KW - estrogens KW - testosterone AU - Ishikawa, T AU - Glidewellkenney, C AU - Jameson, J PY - 2006/02// UR - http://dx.doi.org/10.1016/j.jsbmb.2005.09.004 ER -