Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes Export

@article{citeulike:4411109, abstract = {ObjectiveTo determine the relationships between androgen receptor CAG repeat polymorphism length (AR CAG), sex hormones and clinical variables in men with type 2 diabetes (DM2). Men with DM2 are known to have a high prevalence of low testosterone levels. Studies suggest that testosterone replacement therapy may improve insulin sensitivity and glycaemic control in men with DM2 and reduces central obesity and serum leptin. AR CAG is known to correlate negatively with AR sensitivity and positively with body fat, insulin levels, and leptin in healthy men. DesignCross-sectional study set in a district general hospital diabetes centre. MethodsSex hormones, AR CAG and symptoms of hypogonadism were assessed in 233 men with DM2. Associations were sought between these variables and others such as obesity, leptin, glycaemic control, and blood pressure. ResultsTestosterone was negatively associated and AR CAG positively associated with obesity and leptin. The associations of AR CAG with leptin and obesity were independent of testosterone, estradiol, gonadotropins, and age. AR CAG was also independently associated with total, bioavailable and free testosterone, LH, waist circumference, body mass index, leptin, and systolic blood pressure. There was no association of AR CAG with sex hormone binding globulin, estradiol, HbA1C or the symptoms of hypogonadism. ConclusionsThe association of longer AR CAG with obesity and leptin suggests that shorter AR CAG may have an influence in maintaining healthy anthropomorphics and metabolism in men with DM2. Testosterone and LH levels are higher in men with longer AR CAG, probably reflecting reduced negative feedback through a less sensitive receptor. 10.1530/EJE-08-0266}, author = {Stanworth, R. D. and Kapoor, D. and Channer, K. S. and Jones, T. H.}, citeulike-article-id = {4411109}, citeulike-linkout-0 = {http://dx.doi.org/10.1530/EJE-08-0266}, citeulike-linkout-1 = {http://www.eje-online.org/cgi/content/abstract/159/6/739}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18805913}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18805913}, day = {1}, doi = {10.1530/EJE-08-0266}, journal = {Eur J Endocrinol}, keywords = {androgen, cag, obesity, receptor, testosterone}, month = {December}, number = {6}, pages = {739--746}, posted-at = {2009-04-27 15:00:40}, priority = {2}, title = {Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes}, url = {http://dx.doi.org/10.1530/EJE-08-0266}, volume = {159}, year = {2008} }

TY - JOUR ID - citeulike:4411109 L3 - citeulike-article-id:4411109 N2 - ObjectiveTo determine the relationships between androgen receptor CAG repeat polymorphism length (AR CAG), sex hormones and clinical variables in men with type 2 diabetes (DM2). Men with DM2 are known to have a high prevalence of low testosterone levels. Studies suggest that testosterone replacement therapy may improve insulin sensitivity and glycaemic control in men with DM2 and reduces central obesity and serum leptin. AR CAG is known to correlate negatively with AR sensitivity and positively with body fat, insulin levels, and leptin in healthy men. DesignCross-sectional study set in a district general hospital diabetes centre. MethodsSex hormones, AR CAG and symptoms of hypogonadism were assessed in 233 men with DM2. Associations were sought between these variables and others such as obesity, leptin, glycaemic control, and blood pressure. ResultsTestosterone was negatively associated and AR CAG positively associated with obesity and leptin. The associations of AR CAG with leptin and obesity were independent of testosterone, estradiol, gonadotropins, and age. AR CAG was also independently associated with total, bioavailable and free testosterone, LH, waist circumference, body mass index, leptin, and systolic blood pressure. There was no association of AR CAG with sex hormone binding globulin, estradiol, HbA1C or the symptoms of hypogonadism. ConclusionsThe association of longer AR CAG with obesity and leptin suggests that shorter AR CAG may have an influence in maintaining healthy anthropomorphics and metabolism in men with DM2. Testosterone and LH levels are higher in men with longer AR CAG, probably reflecting reduced negative feedback through a less sensitive receptor. 10.1530/EJE-08-0266 IS - 6 JF - Eur J Endocrinol EP - 746 TI - Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes VL - 159 SP - 739 KW - androgen KW - cag KW - obesity KW - receptor KW - testosterone AU - Stanworth, RD AU - Kapoor, D AU - Channer, KS AU - Jones, TH PY - 2008/12/01/ UR - http://dx.doi.org/10.1530/EJE-08-0266 ER -