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Regulation of Sex-Hormone-Binding Globulin Production by Endogenous Estrogens in Vitro Export

by: M. Loukovaara
Biochemical and Biophysical Research Communications, Vol. 206, No. 3. (26 January 1995), pp. 895-901.

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estrogens regulation shbg

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The effect of endogenous estrogens on sex-hormone-binding globulin (SHBG) production was studied in HepG2 cells. 17β-estradiol, estrone, and estrogens from both 2-and 16α-hydroxylative pathways stimulated SHBG production, but not in parallel with their binding affinities for the estrogen receptor. Thus, the underlying mechanism may be other than a pure interaction with the estrogen receptor.


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