The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. Export

@article{citeulike:4464061, abstract = {Twenty-three middle-aged abdominally obese men were treated for eight months with testosterone or with placebo. Testosterone treatment was followed by a decrease of visceral fat mass, measured by computerized tomography, without a change in body mass, subcutaneous fat mass or lean body mass. Insulin resistance, measured by the euglycemic/hyperinsulinemic glucose clamp method, improved and blood glucose, diastolic blood pressure and serum cholesterol decreased with testosterone treatment. A small increase in prostate volume was noted, but serum prostate specific antigen concentrations were unchanged and no adverse functional side-effects were found. Insulin sensitivity improved more in men with relatively low testosterone values at the outset. The mechanisms involved in these changes might act either via effects on visceral fat accumulation, followed by metabolic improvements, and/or via direct effects on muscle insulin sensitivity, as suggested by results of other recent studies. It is concluded that testosterone treatment of middle-aged abdominally obese men gives beneficial effects on well-being and the cardiovascular and diabetes risk profile, results similar to those observed after hormonal replacement therapy in postmenopausal women.}, author = {M\r{a}rin, P. and Holm\"{a}ng, S. and J\"{o}nsson, L. and Sj\"{o}str\"{o}m, L. and Kvist, H. and Holm, G. and Lindstedt, G. and Bj\"{o}rntorp, P.}, citeulike-article-id = {4464061}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/1335979}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=1335979}, issn = {0307-0565}, journal = {International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity}, keywords = {adipose, adiposity, fat, men, obese, obesity, replacement, testosterone}, month = {December}, number = {12}, pages = {991--997}, posted-at = {2009-05-05 13:13:34}, priority = {2}, title = {The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1335979}, volume = {16}, year = {1992} }

TY - JOUR ID - citeulike:4464061 L3 - citeulike-article-id:4464061 N2 - Twenty-three middle-aged abdominally obese men were treated for eight months with testosterone or with placebo. Testosterone treatment was followed by a decrease of visceral fat mass, measured by computerized tomography, without a change in body mass, subcutaneous fat mass or lean body mass. Insulin resistance, measured by the euglycemic/hyperinsulinemic glucose clamp method, improved and blood glucose, diastolic blood pressure and serum cholesterol decreased with testosterone treatment. A small increase in prostate volume was noted, but serum prostate specific antigen concentrations were unchanged and no adverse functional side-effects were found. Insulin sensitivity improved more in men with relatively low testosterone values at the outset. The mechanisms involved in these changes might act either via effects on visceral fat accumulation, followed by metabolic improvements, and/or via direct effects on muscle insulin sensitivity, as suggested by results of other recent studies. It is concluded that testosterone treatment of middle-aged abdominally obese men gives beneficial effects on well-being and the cardiovascular and diabetes risk profile, results similar to those observed after hormonal replacement therapy in postmenopausal women. IS - 12 JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity SN - 0307-0565 EP - 997 TI - The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. VL - 16 SP - 991 KW - adipose KW - adiposity KW - fat KW - men KW - obese KW - obesity KW - replacement KW - testosterone AU - Mårin, P AU - Holmäng, S AU - Jönsson, L AU - Sjöström, L AU - Kvist, H AU - Holm, G AU - Lindstedt, G AU - Björntorp, P PY - 1992/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/1335979 ER -