Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones Export

@article{citeulike:4464643, abstract = {This study presents the reactions of adrenocorticosteroids (cortisol and aldosterone) and sex steroids [testosterone, androstenedione, and dehydroepiandrosterone and its sulfate (DHAS)] 1) to a dexamethasone (Dex) treatment, which is expected to lower steroid levels via the ACTH blockade, and 2) to an exercise bout at maximal O2 consumption, which is expected to increase steroid production via ACTH stimulation. Consistent with the decrease in ACTH, all steroids except testosterone reacted negatively to Dex, independently of the dose (0.5 and 1.5 mg administered twice daily for 4.5 days). After exercise, plasma ACTH rose to 600\% of basal value, resulting in a significant increase in aldosterone and adrenal androgens, but cortisol and DHAS were unaffected. This apparently surprising result can be explained by differences in peripheral metabolism: a theoretical calculation predicted that after 15 min the increase in hormone concentration may only reach 12\% for cortisol and 2\% for DHAS. For cortisol and adrenal androgens, assays were carried out using plasma and saliva. The consistent results obtained from the two matrices allow us to consider salivary assays as a useful tool for steroid abuse detection.}, author = {Lac, G. and Marquet, P. and Chassain, A. P. and Galen, F. X.}, citeulike-article-id = {4464643}, citeulike-linkout-0 = {http://jap.physiology.org/cgi/content/abstract/87/1/183}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10409573}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10409573}, day = {1}, journal = {J Appl Physiol}, keywords = {adrenal, androgens, dexamethasone}, month = {July}, number = {1}, pages = {183--188}, posted-at = {2009-05-05 16:14:44}, priority = {2}, title = {Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones}, url = {http://jap.physiology.org/cgi/content/abstract/87/1/183}, volume = {87}, year = {1999} }

TY - JOUR ID - citeulike:4464643 L3 - citeulike-article-id:4464643 N2 - This study presents the reactions of adrenocorticosteroids (cortisol and aldosterone) and sex steroids [testosterone, androstenedione, and dehydroepiandrosterone and its sulfate (DHAS)] 1) to a dexamethasone (Dex) treatment, which is expected to lower steroid levels via the ACTH blockade, and 2) to an exercise bout at maximal O2 consumption, which is expected to increase steroid production via ACTH stimulation. Consistent with the decrease in ACTH, all steroids except testosterone reacted negatively to Dex, independently of the dose (0.5 and 1.5 mg administered twice daily for 4.5 days). After exercise, plasma ACTH rose to 600% of basal value, resulting in a significant increase in aldosterone and adrenal androgens, but cortisol and DHAS were unaffected. This apparently surprising result can be explained by differences in peripheral metabolism: a theoretical calculation predicted that after 15 min the increase in hormone concentration may only reach 12% for cortisol and 2% for DHAS. For cortisol and adrenal androgens, assays were carried out using plasma and saliva. The consistent results obtained from the two matrices allow us to consider salivary assays as a useful tool for steroid abuse detection. IS - 1 JF - J Appl Physiol EP - 188 TI - Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones VL - 87 SP - 183 KW - adrenal KW - androgens KW - dexamethasone AU - Lac, G AU - Marquet, P AU - Chassain, AP AU - Galen, FX PY - 1999/07/01/ UR - http://jap.physiology.org/cgi/content/abstract/87/1/183 ER -