Obesity and testicular function. Export

@article{citeulike:5366338, abstract = {Obesity in men, particularly when central, is associated with lower total testosterone [TT], free testosterone [FT] and sex hormone-binding globulin [SHBG], and a greater decline in TT and FT with increasing age compared with lean men. Obesity-related conditions such as obstructive sleep apnea, insulin resistance and type 2 diabetes mellitus are independently associated with decreased plasma testosterone. Possible mechanisms include decreased LH pulse amplitude, inhibitory effects of oestrogen at the hypothalamus and pituitary and the effects of leptin and other peptides centrally and on Leydig cells. Obese men have reduced sperm concentration and total sperm count compared to lean men but sperm motility and morphology appear unaffected. The cause and effect relationships between low plasma androgen levels, obesity and the metabolic syndrome, and associated cardiometabolic risk remain unclear. While weight loss normalizes TT and FT in obese men, androgen replacement in the short term does not significantly improve cardiometabolic risk profile despite reducing fat mass.}, author = {Mah, P. M. and Wittert, G. A.}, citeulike-article-id = {5366338}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.mce.2009.06.007}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0303720709003475}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19540307}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19540307}, day = {18}, doi = {10.1016/j.mce.2009.06.007}, issn = {1872-8057}, journal = {Molecular and cellular endocrinology}, keywords = {androgens, diabetes, human, men, obesity, testicular\_function, testosterone}, month = {June}, posted-at = {2009-10-31 12:12:41}, priority = {2}, title = {Obesity and testicular function.}, url = {http://dx.doi.org/10.1016/j.mce.2009.06.007}, year = {2009} }

TY - JOUR ID - citeulike:5366338 L3 - citeulike-article-id:5366338 N2 - Obesity in men, particularly when central, is associated with lower total testosterone [TT], free testosterone [FT] and sex hormone-binding globulin [SHBG], and a greater decline in TT and FT with increasing age compared with lean men. Obesity-related conditions such as obstructive sleep apnea, insulin resistance and type 2 diabetes mellitus are independently associated with decreased plasma testosterone. Possible mechanisms include decreased LH pulse amplitude, inhibitory effects of oestrogen at the hypothalamus and pituitary and the effects of leptin and other peptides centrally and on Leydig cells. Obese men have reduced sperm concentration and total sperm count compared to lean men but sperm motility and morphology appear unaffected. The cause and effect relationships between low plasma androgen levels, obesity and the metabolic syndrome, and associated cardiometabolic risk remain unclear. While weight loss normalizes TT and FT in obese men, androgen replacement in the short term does not significantly improve cardiometabolic risk profile despite reducing fat mass. JF - Molecular and cellular endocrinology SN - 1872-8057 TI - Obesity and testicular function. KW - androgens KW - diabetes KW - human KW - men KW - obesity KW - testicular_function KW - testosterone AU - Mah, PM AU - Wittert, GA PY - 2009/06/18/ UR - http://dx.doi.org/10.1016/j.mce.2009.06.007 ER -