Growth Hormone and Sex Steroid Effects on Serum Glucose, Insulin, and Lipid Concentrations in Healthy Older Women and Men Export

@article{citeulike:6048031, abstract = {Context: With aging, GH, IGF-I, and sex steroid concentrations and glucose tolerance decrease, and body fat and serum lipids increase. Objective: The aim of the study was to assess GH and/or sex steroid administration effects on serum glucose, insulin, insulin sensitivity, and lipids in older individuals. Design: A double-masked, 2 x 2 factorial, placebo-controlled, double-dummy design was used for the study. Intervention: GH and/or sex steroid [transdermal estradiol plus oral medroxyprogesterone acetate in women (HRT); testosterone enanthate (T) in men] were administered for 6 months. Participants: Healthy, community-dwelling women (n = 57) and men (n = 74) ages 65-88 yr (mean, 72 yr) participated in the study. Main Outcome Measures: We measured serum glucose, insulin, and insulin sensitivity [quantitative insulin sensitivity check index (QUICKI) and insulin sensitivity index (ISI)] before and during an oral glucose tolerance test and lipid profiles. Results: In women, GH did not alter oral glucose tolerance test 120 min or 2-h area under the curve (AUC) glucose values, but it increased 120 min insulin and AUC insulin. There were no significant effects of HRT or GH+HRT. ISI and QUICKI decreased after GH. In men, GH increased 120 min and AUC glucose and insulin AUC. GH+T increased 120 min glucose and glucose and insulin AUCs. T alone did not affect glucose or insulin. ISI decreased after GH and GH+T, whereas QUICKI decreased after GH. GH in women and men and GH+T in men decreased QUICKI by 4 wk. In women, HRT decreased total cholesterol and low-density lipoprotein (LDL)-cholesterol, and GH decreased LDL-cholesterol. In men, total cholesterol decreased after T and GH+T. LDL-cholesterol decreased after GH and GH+T. GH increased serum triglycerides. Conclusions: GH administration to healthy older individuals for 6 months increased insulin resistance with moderately beneficial effects on lipids. 10.1210/jc.2009-1275}, author = {Munzer, Thomas and Harman, S. Mitchell and Sorkin, John D. and Blackman, Marc R.}, citeulike-article-id = {6048031}, citeulike-linkout-0 = {http://dx.doi.org/10.1210/jc.2009-1275}, citeulike-linkout-1 = {http://jcem.endojournals.org/content/94/10/3833.abstract}, citeulike-linkout-2 = {http://jcem.endojournals.org/content/94/10/3833.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19602554}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19602554}, day = {1}, doi = {10.1210/jc.2009-1275}, journal = {J Clin Endocrinol Metab}, keywords = {androgens, estrogens, glucose, growth, hormone, human, testosterone}, month = {October}, number = {10}, pages = {3833--3841}, posted-at = {2009-10-31 12:19:30}, priority = {2}, title = {Growth Hormone and Sex Steroid Effects on Serum Glucose, Insulin, and Lipid Concentrations in Healthy Older Women and Men}, url = {http://dx.doi.org/10.1210/jc.2009-1275}, volume = {94}, year = {2009} }

TY - JOUR ID - citeulike:6048031 L3 - citeulike-article-id:6048031 N2 - Context: With aging, GH, IGF-I, and sex steroid concentrations and glucose tolerance decrease, and body fat and serum lipids increase. Objective: The aim of the study was to assess GH and/or sex steroid administration effects on serum glucose, insulin, insulin sensitivity, and lipids in older individuals. Design: A double-masked, 2 x 2 factorial, placebo-controlled, double-dummy design was used for the study. Intervention: GH and/or sex steroid [transdermal estradiol plus oral medroxyprogesterone acetate in women (HRT); testosterone enanthate (T) in men] were administered for 6 months. Participants: Healthy, community-dwelling women (n = 57) and men (n = 74) ages 65-88 yr (mean, 72 yr) participated in the study. Main Outcome Measures: We measured serum glucose, insulin, and insulin sensitivity [quantitative insulin sensitivity check index (QUICKI) and insulin sensitivity index (ISI)] before and during an oral glucose tolerance test and lipid profiles. Results: In women, GH did not alter oral glucose tolerance test 120 min or 2-h area under the curve (AUC) glucose values, but it increased 120 min insulin and AUC insulin. There were no significant effects of HRT or GH+HRT. ISI and QUICKI decreased after GH. In men, GH increased 120 min and AUC glucose and insulin AUC. GH+T increased 120 min glucose and glucose and insulin AUCs. T alone did not affect glucose or insulin. ISI decreased after GH and GH+T, whereas QUICKI decreased after GH. GH in women and men and GH+T in men decreased QUICKI by 4 wk. In women, HRT decreased total cholesterol and low-density lipoprotein (LDL)-cholesterol, and GH decreased LDL-cholesterol. In men, total cholesterol decreased after T and GH+T. LDL-cholesterol decreased after GH and GH+T. GH increased serum triglycerides. Conclusions: GH administration to healthy older individuals for 6 months increased insulin resistance with moderately beneficial effects on lipids. 10.1210/jc.2009-1275 IS - 10 JF - J Clin Endocrinol Metab EP - 3841 TI - Growth Hormone and Sex Steroid Effects on Serum Glucose, Insulin, and Lipid Concentrations in Healthy Older Women and Men VL - 94 SP - 3833 KW - androgens KW - estrogens KW - glucose KW - growth KW - hormone KW - human KW - testosterone AU - Munzer, Thomas AU - Harman, Mitchell AU - Sorkin, John AU - Blackman, Marc PY - 2009/10/01/ UR - http://dx.doi.org/10.1210/jc.2009-1275 ER -