Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men Export

@article{citeulike:6048106, abstract = {Context: Impairments in the pituitary-gonadal axis with aging are associated with loss of muscle mass and function and accumulation of upper body fat. Objectives: We tested the hypothesis that physiological supplementation with testosterone and GH together improves body composition and muscle performance in older men. Design, Setting, and Participants: One hundred twenty-two community-dwelling men 70.8 {+/-} 4.2 yr of age with body mass index of 27.4 {+/-} 3.4 kg/m2, testosterone of 550 ng/dl or less, and IGF-I in lower adult tertile ([\&le;]167 ng/dl) were randomized to receive transdermal testosterone (5 or 10 g/d) during a Leydig cell clamp plus GH (0, 3, or 5 {micro}g/kg {middle dot} d) for 16 wk. Main Outcome Measures: Body composition by dual-energy x-ray absorptiometry, muscle performance, and safety tests were conducted. Results: Total lean body mass increased (1.0 {+/-} 1.7 to 3.0 {+/-} 2.2 kg) as did appendicular lean tissue (0.4 {+/-} 1.4 to 1.5 {+/-} 1.3 kg), whereas total fat mass decreased by 0.4 {+/-} 0.9 to 2.3 {+/-} 1.7 kg as did trunk fat (0.5 {+/-} 0.9 to 1.5 {+/-} 1.0 kg) across the six treatment groups and by dose levels for each parameter (P [\&le;] 0.0004 for linear trend). Composite maximum voluntary strength of upper and lower body muscles increased by 14 {+/-} 34 to 35 {+/-} 31\% (P < 0.003 in the three highest dose groups) that correlated with changes in appendicular lean mass. Aerobic endurance increased in all six groups (average 96 {+/-} 137sec longer). Systolic and diastolic blood pressure increased similarly in each group with mean increases of 12 {+/-} 14 and 8 {+/-} 8 mm Hg, respectively. Other predictable adverse events were modest and reversible. Conclusions: Supplemental testosterone produced significant gains in total and appendicular lean mass, muscle strength, and aerobic endurance with significant reductions in whole-body and trunk fat. Outcomes appeared to be further enhanced with GH supplementation. 10.1210/jc.2008-2338}, author = {Sattler, Fred R. and Castaneda-Sceppa, Carmen and Binder, Ellen F. and Schroeder, E. Todd and Wang, Ying and Bhasin, Shalender and Kawakubo, Miwa and Stewart, Yolanda and Yarasheski, Kevin E. and Ulloor, Jagadish and Colletti, Patrick and Roubenoff, Ronenn and Azen, Stanley P.}, citeulike-article-id = {6048106}, citeulike-linkout-0 = {http://dx.doi.org/10.1210/jc.2008-2338}, citeulike-linkout-1 = {http://jcem.endojournals.org/content/94/6/1991.abstract}, citeulike-linkout-2 = {http://jcem.endojournals.org/content/94/6/1991.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19293261}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19293261}, day = {1}, doi = {10.1210/jc.2008-2338}, journal = {J Clin Endocrinol Metab}, keywords = {androgens, body\_composition, growth\_hormone, human, men, muscle, testosterone}, month = {June}, number = {6}, pages = {1991--2001}, posted-at = {2009-10-31 12:21:53}, priority = {2}, title = {Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men}, url = {http://dx.doi.org/10.1210/jc.2008-2338}, volume = {94}, year = {2009} }

TY - JOUR ID - citeulike:6048106 L3 - citeulike-article-id:6048106 N2 - Context: Impairments in the pituitary-gonadal axis with aging are associated with loss of muscle mass and function and accumulation of upper body fat. Objectives: We tested the hypothesis that physiological supplementation with testosterone and GH together improves body composition and muscle performance in older men. Design, Setting, and Participants: One hundred twenty-two community-dwelling men 70.8 {+/-} 4.2 yr of age with body mass index of 27.4 {+/-} 3.4 kg/m2, testosterone of 550 ng/dl or less, and IGF-I in lower adult tertile ([&le;]167 ng/dl) were randomized to receive transdermal testosterone (5 or 10 g/d) during a Leydig cell clamp plus GH (0, 3, or 5 {micro}g/kg {middle dot} d) for 16 wk. Main Outcome Measures: Body composition by dual-energy x-ray absorptiometry, muscle performance, and safety tests were conducted. Results: Total lean body mass increased (1.0 {+/-} 1.7 to 3.0 {+/-} 2.2 kg) as did appendicular lean tissue (0.4 {+/-} 1.4 to 1.5 {+/-} 1.3 kg), whereas total fat mass decreased by 0.4 {+/-} 0.9 to 2.3 {+/-} 1.7 kg as did trunk fat (0.5 {+/-} 0.9 to 1.5 {+/-} 1.0 kg) across the six treatment groups and by dose levels for each parameter (P [&le;] 0.0004 for linear trend). Composite maximum voluntary strength of upper and lower body muscles increased by 14 {+/-} 34 to 35 {+/-} 31% (P < 0.003 in the three highest dose groups) that correlated with changes in appendicular lean mass. Aerobic endurance increased in all six groups (average 96 {+/-} 137sec longer). Systolic and diastolic blood pressure increased similarly in each group with mean increases of 12 {+/-} 14 and 8 {+/-} 8 mm Hg, respectively. Other predictable adverse events were modest and reversible. Conclusions: Supplemental testosterone produced significant gains in total and appendicular lean mass, muscle strength, and aerobic endurance with significant reductions in whole-body and trunk fat. Outcomes appeared to be further enhanced with GH supplementation. 10.1210/jc.2008-2338 IS - 6 JF - J Clin Endocrinol Metab EP - 2001 TI - Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men VL - 94 SP - 1991 KW - androgens KW - body_composition KW - growth_hormone KW - human KW - men KW - muscle KW - testosterone AU - Sattler, Fred AU - Castaneda-Sceppa, Carmen AU - Binder, Ellen AU - Schroeder, Todd AU - Wang, Ying AU - Bhasin, Shalender AU - Kawakubo, Miwa AU - Stewart, Yolanda AU - Yarasheski, Kevin AU - Ulloor, Jagadish AU - Colletti, Patrick AU - Roubenoff, Ronenn AU - Azen, Stanley PY - 2009/06/01/ UR - http://dx.doi.org/10.1210/jc.2008-2338 ER -