The role of estrogens for male bone health Export

@article{citeulike:6082017, abstract = {Sex steroids are important for the growth and maintenance of both the female and the male skeleton. However, the relative contribution of androgens versus estrogens in the regulation of the male skeleton is unclear. Experiments using mice with inactivated sex steroid receptors demonstrated that both activation of the estrogen receptor (ER){alpha} and activation of the androgen receptor result in a stimulatory effect on both the cortical and trabecular bone mass in males. ER{beta} is of no importance for the skeleton in male mice while it modulates the ER{alpha}-action on bone in female mice. Previous in vitro studies suggest that the membrane G protein-coupled receptor GPR30 also might be a functional ER. Our in vivo analyses of GPR30-inactivated mice revealed no function of GPR30 for estrogen-mediated effects on bone mass but it is required for normal regulation of the growth plate and estrogen-mediated insulin-secretion. Recent clinical evidence suggests that a threshold exists for estrogen effects on bone in men: rates of bone loss and fracture risk seem to be the highest in men with estradiol levels below this threshold. Taken together, even though these findings do not exclude an important role for testosterone in male skeletal homeostasis, it is now well-established that estrogens are important regulators of bone health in men. 10.1530/EJE-09-0118}, author = {Ohlsson, Claes and Vandenput, Liesbeth}, citeulike-article-id = {6082017}, citeulike-linkout-0 = {http://dx.doi.org/10.1530/EJE-09-0118}, citeulike-linkout-1 = {http://www.eje-online.org/content/160/6/883.abstract}, citeulike-linkout-2 = {http://www.eje-online.org/content/160/6/883.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19304870}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19304870}, day = {1}, doi = {10.1530/EJE-09-0118}, journal = {Eur J Endocrinol}, keywords = {estrogens, human, men, osteoporosis, review}, month = {June}, number = {6}, pages = {883--889}, posted-at = {2009-11-07 08:58:12}, priority = {2}, title = {The role of estrogens for male bone health}, url = {http://dx.doi.org/10.1530/EJE-09-0118}, volume = {160}, year = {2009} }

TY - JOUR ID - citeulike:6082017 L3 - citeulike-article-id:6082017 N2 - Sex steroids are important for the growth and maintenance of both the female and the male skeleton. However, the relative contribution of androgens versus estrogens in the regulation of the male skeleton is unclear. Experiments using mice with inactivated sex steroid receptors demonstrated that both activation of the estrogen receptor (ER){alpha} and activation of the androgen receptor result in a stimulatory effect on both the cortical and trabecular bone mass in males. ER{beta} is of no importance for the skeleton in male mice while it modulates the ER{alpha}-action on bone in female mice. Previous in vitro studies suggest that the membrane G protein-coupled receptor GPR30 also might be a functional ER. Our in vivo analyses of GPR30-inactivated mice revealed no function of GPR30 for estrogen-mediated effects on bone mass but it is required for normal regulation of the growth plate and estrogen-mediated insulin-secretion. Recent clinical evidence suggests that a threshold exists for estrogen effects on bone in men: rates of bone loss and fracture risk seem to be the highest in men with estradiol levels below this threshold. Taken together, even though these findings do not exclude an important role for testosterone in male skeletal homeostasis, it is now well-established that estrogens are important regulators of bone health in men. 10.1530/EJE-09-0118 IS - 6 JF - Eur J Endocrinol EP - 889 TI - The role of estrogens for male bone health VL - 160 SP - 883 KW - estrogens KW - human KW - men KW - osteoporosis KW - review AU - Ohlsson, Claes AU - Vandenput, Liesbeth PY - 2009/06/01/ UR - http://dx.doi.org/10.1530/EJE-09-0118 ER -