Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions. Export

@article{citeulike:3191743, abstract = {The broadly distributed monoaminergic neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) exerts its actions via 14 classes of receptor. With the exception of 5-HT(3) receptors, which gate a cation-permeable ion channel, all 5-HT receptors are coupled to G proteins. The core features of transduction via 5-HT receptors are well established, but much still remains to be learned, in particular, with regard to native populations in the brain. In this article, we survey the current knowledge of cellular signaling at G-protein-coupled 5-HT receptors and focus on several novel (and surprising) insights that have emerged over the past few years. We also highlight several promising directions for future research that should improve the understanding of serotonin signaling and ultimately permit its therapeutic exploitation in the control of central nervous system disorders. In view of the diversity of transduction mechanisms engaged by 5-HT, much of this discussion is relevant to other classes of G-protein-coupled receptors.}, address = {Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, Paris, France.}, author = {Millan, Mark J J. and Marin, Philippe and Bockaert, Jo\"{e}l and Mannoury la Cour, Clotilde}, citeulike-article-id = {3191743}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tips.2008.06.007}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18676031}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18676031}, day = {12}, doi = {10.1016/j.tips.2008.06.007}, issn = {0165-6147}, journal = {Trends in pharmacological sciences}, keywords = {5-ht, 5-ht1, 5-ht1a, 5-ht2c, 5-ht4, 5-ht7, 5ht, 5ht6, 7tm-receptor, g-protein, gpcr, receptor, serotonin}, month = {August}, posted-at = {2008-09-04 13:44:38}, priority = {2}, title = {Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.}, url = {http://dx.doi.org/10.1016/j.tips.2008.06.007}, year = {2008} }

TY - JOUR ID - citeulike:3191743 L3 - citeulike-article-id:3191743 N2 - The broadly distributed monoaminergic neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) exerts its actions via 14 classes of receptor. With the exception of 5-HT(3) receptors, which gate a cation-permeable ion channel, all 5-HT receptors are coupled to G proteins. The core features of transduction via 5-HT receptors are well established, but much still remains to be learned, in particular, with regard to native populations in the brain. In this article, we survey the current knowledge of cellular signaling at G-protein-coupled 5-HT receptors and focus on several novel (and surprising) insights that have emerged over the past few years. We also highlight several promising directions for future research that should improve the understanding of serotonin signaling and ultimately permit its therapeutic exploitation in the control of central nervous system disorders. In view of the diversity of transduction mechanisms engaged by 5-HT, much of this discussion is relevant to other classes of G-protein-coupled receptors. JF - Trends in pharmacological sciences SN - 0165-6147 AD - Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, Paris, France. TI - Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions. KW - 5-ht KW - 5-ht1 KW - 5-ht1a KW - 5-ht2c KW - 5-ht4 KW - 5-ht7 KW - 5ht KW - 5ht6 KW - 7tm-receptor KW - g-protein KW - gpcr KW - receptor KW - serotonin AU - Millan, Mark J AU - Marin, Philippe AU - Bockaert, Joël AU - Mannoury la Cour, Clotilde PY - 2008/08/12/ UR - http://dx.doi.org/10.1016/j.tips.2008.06.007 ER -