Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia. Export

@article{citeulike:3292932, abstract = {The cyclic adenosine monophosphate (cAMP) is a second messenger and a central component of intracellular signaling pathways that regulate a wide range of biological functions, including memory. Hence, in this work, firstly the time-course of memory formation was determined in an autoshaping learning task, which had allowed the identification of testing times for increases or decreases in performance. Next, untrained, trained and overtrained groups were compared in cAMP production. Moreover, selective stimulation and antagonism of 5-HT(1A) and 5-HT(7) receptors during memory formation and cAMP production were determined. Finally, since there is scarce information about how pharmacological models of amnesia affect cAMP production, the cholinergic or glutamatergic antagonists, scopolamine and dizocilpine, were tested. The major findings of this work showed that when the time-course was determined inasmuch as training and testing sessions occurred, memory performance was graduate and progressive. Notably, for the fourth to seventh (i.e., 48-120h following autoshaping training session) testing session performance was significantly higher from the previous ones. When animals received 5-HT(1A) and 5-HT(7) receptor agonists and antagonists or amnesic drugs significant increases or decrements in memory performance were observed at 24 and 48h. Moreover, when ex vivo cAMP production from trained and overtrained groups were compared to untrained ones, significant differences were observed among groups and brain areas. Trained animals treated with 8-OHDPAT, AS19, 8-OHDPAT plus AS19, WAY100635, SB-269970, scopolamine or dizocilpine were compared to similar untrained groups, and eightfold-reduced cAMP production was evident, showing the importance of cAMP production in the signaling case in mammalian memory formation.}, address = {Department of Pharmacobiology, CINVESTAV, Tenorios 235, Granjas Coapa, 14330 Mexico City, Mexico.}, author = {Perez-Garc\'{\i}a, G and Meneses, A}, citeulike-article-id = {3292932}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbr.2008.07.033}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18723050}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18723050}, day = {3}, doi = {10.1016/j.bbr.2008.07.033}, issn = {0166-4328}, journal = {Behavioural brain research}, keywords = {5-ht1a, 5-ht7antagonist, agonist, antagonist, memory}, month = {August}, posted-at = {2008-09-19 14:38:42}, priority = {2}, title = {Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia.}, url = {http://dx.doi.org/10.1016/j.bbr.2008.07.033}, year = {2008} }

TY - JOUR ID - citeulike:3292932 L3 - citeulike-article-id:3292932 N2 - The cyclic adenosine monophosphate (cAMP) is a second messenger and a central component of intracellular signaling pathways that regulate a wide range of biological functions, including memory. Hence, in this work, firstly the time-course of memory formation was determined in an autoshaping learning task, which had allowed the identification of testing times for increases or decreases in performance. Next, untrained, trained and overtrained groups were compared in cAMP production. Moreover, selective stimulation and antagonism of 5-HT(1A) and 5-HT(7) receptors during memory formation and cAMP production were determined. Finally, since there is scarce information about how pharmacological models of amnesia affect cAMP production, the cholinergic or glutamatergic antagonists, scopolamine and dizocilpine, were tested. The major findings of this work showed that when the time-course was determined inasmuch as training and testing sessions occurred, memory performance was graduate and progressive. Notably, for the fourth to seventh (i.e., 48-120h following autoshaping training session) testing session performance was significantly higher from the previous ones. When animals received 5-HT(1A) and 5-HT(7) receptor agonists and antagonists or amnesic drugs significant increases or decrements in memory performance were observed at 24 and 48h. Moreover, when ex vivo cAMP production from trained and overtrained groups were compared to untrained ones, significant differences were observed among groups and brain areas. Trained animals treated with 8-OHDPAT, AS19, 8-OHDPAT plus AS19, WAY100635, SB-269970, scopolamine or dizocilpine were compared to similar untrained groups, and eightfold-reduced cAMP production was evident, showing the importance of cAMP production in the signaling case in mammalian memory formation. JF - Behavioural brain research SN - 0166-4328 AD - Department of Pharmacobiology, CINVESTAV, Tenorios 235, Granjas Coapa, 14330 Mexico City, Mexico. TI - Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia. KW - 5-ht1a KW - 5-ht7antagonist KW - agonist KW - antagonist KW - memory AU - Perez-García, G AU - Meneses, A PY - 2008/08/03/ UR - http://dx.doi.org/10.1016/j.bbr.2008.07.033 ER -