Original CIN: reviewing roles for APC in chromosome instability. Export

@article{citeulike:3644476, abstract = {You may have seen the bumper sticker "Eve was framed." Thousands of years of being blamed for original sin and still many wonder, where's the evidence? Today, the tumor suppressor adenomatous polyposis coli (APC) may have the same complaint about accusations of a different type of CIN, chromosome instability. A series of recent papers, including three in this journal, propose that loss of APC function plays an important role in the CIN seen in many colon cancer cells. However, a closer look reveals a complex story that raises more questions than answers.}, author = {Rusan, N. M. and Peifer, M.}, citeulike-article-id = {3644476}, citeulike-linkout-0 = {http://dx.doi.org/10.1083/jcb.200802107}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18519734}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18519734}, day = {2}, doi = {10.1083/jcb.200802107}, issn = {1540-8140}, journal = {The Journal of cell biology}, keywords = {apc, chromosomal, colon, colorectal, fap, instability}, month = {June}, number = {5}, pages = {719--726}, posted-at = {2008-11-21 11:27:35}, priority = {2}, title = {Original CIN: reviewing roles for APC in chromosome instability.}, url = {http://dx.doi.org/10.1083/jcb.200802107}, volume = {181}, year = {2008} }

TY - JOUR ID - citeulike:3644476 L3 - citeulike-article-id:3644476 N2 - You may have seen the bumper sticker "Eve was framed." Thousands of years of being blamed for original sin and still many wonder, where's the evidence? Today, the tumor suppressor adenomatous polyposis coli (APC) may have the same complaint about accusations of a different type of CIN, chromosome instability. A series of recent papers, including three in this journal, propose that loss of APC function plays an important role in the CIN seen in many colon cancer cells. However, a closer look reveals a complex story that raises more questions than answers. IS - 5 JF - The Journal of cell biology SN - 1540-8140 EP - 726 TI - Original CIN: reviewing roles for APC in chromosome instability. VL - 181 SP - 719 KW - apc KW - chromosomal KW - colon KW - colorectal KW - fap KW - instability AU - Rusan, NM AU - Peifer, M PY - 2008/06/02/ UR - http://dx.doi.org/10.1083/jcb.200802107 ER -