MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo Export

@article{krmpotic_mcmv_2002, abstract = {The susceptibility of certain inbred mouse strains to murine cytomegalovirus (MCMV) is related to their inability to generate a strong natural killer (NK) cell response. We addressed here whether the MCMV susceptibility of the BALB/c strain is due to viral functions that control NK cell activation in a strain-specific manner. MCMV expresses two proteins, gp48 and gp40, that are encoded by the genes m06 and m152, respectively; they down-regulate major histocompatibility complex (MHC) class I expression at the plasma membrane. Using MCMV deletion mutants and revertants, we found that gp40 but not gp48 controls NK cell activation. Absence of gp40 improved antiviral NK cell control in BALB/c, but not C57BL/6, mice. Down-regulation of H-60, the high-affinity ligand for the NKG2D receptor, was the mechanism by which gp40 modulates NK cell activation. Thus, a single herpesvirus protein has a dual function in inhibiting both the adaptive as well as the innate immune response.}, author = {Krmpotic, Astrid and Busch, Dirk H. and Bubic, Ivan and Gebhardt, Friedemann and Hengel, Hartmut and Hasan, Milena and Scalzo, Anthony A. and Koszinowski, Ulrich H. and Jonjicstipan}, citeulike-article-id = {2705409}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ni799}, doi = {10.1038/ni799}, journal = {Nat Immunol}, keywords = {cancer, cmv, ctl, mhc, nk, virus}, pages = {529--535}, posted-at = {2008-04-23 05:48:08}, priority = {0}, title = {MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo}, url = {http://dx.doi.org/10.1038/ni799}, volume = {3}, year = {2002} }

TY - JOUR ID - krmpotic_mcmv_2002 L3 - citeulike-article-id:2705409 N2 - The susceptibility of certain inbred mouse strains to murine cytomegalovirus (MCMV) is related to their inability to generate a strong natural killer (NK) cell response. We addressed here whether the MCMV susceptibility of the BALB/c strain is due to viral functions that control NK cell activation in a strain-specific manner. MCMV expresses two proteins, gp48 and gp40, that are encoded by the genes m06 and m152, respectively; they down-regulate major histocompatibility complex (MHC) class I expression at the plasma membrane. Using MCMV deletion mutants and revertants, we found that gp40 but not gp48 controls NK cell activation. Absence of gp40 improved antiviral NK cell control in BALB/c, but not C57BL/6, mice. Down-regulation of H-60, the high-affinity ligand for the NKG2D receptor, was the mechanism by which gp40 modulates NK cell activation. Thus, a single herpesvirus protein has a dual function in inhibiting both the adaptive as well as the innate immune response. JF - Nat Immunol EP - 535 TI - MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo VL - 3 SP - 529 KW - cancer KW - cmv KW - ctl KW - mhc KW - nk KW - virus AU - Krmpotic, Astrid AU - Busch, Dirk AU - Bubic, Ivan AU - Gebhardt, Friedemann AU - Hengel, Hartmut AU - Hasan, Milena AU - Scalzo, Anthony AU - Koszinowski, Ulrich AU - Jonjicstipan PY - 2002/// UR - http://dx.doi.org/10.1038/ni799 ER -