The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151 Export

@misc{inhibition, abstract = {n vivo tumor cell migration through integrin-dependent pathways is key to the metastatic behavior of malignant cells. Using quantitative in vivo assays and intravital imaging, we assessed the impact of cell migration, regulated by the integrin-associated tetraspanin CD151, on spontaneous human tumor cell metastasis. We demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site. In vivo, this loss of migration is the result of enhanced tumor cell-matrix interactions, promoted by CD151, which prevent dissociation by individual cells and leads to a subsequent inhibition of invasion and intravasation at the site of the primary tumor.}, citeulike-article-id = {2705441}, citeulike-linkout-0 = {http://www.sciencedirect.com.libproxy1.nus.edu.sg/science/article/B6WWK-4S1BVT4-7/2/0207748e31078d47895d75acb7d7d364}, keywords = {cancer, cd151, metastasis}, posted-at = {2008-04-23 05:48:12}, priority = {0}, title = {The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151}, url = {http://www.sciencedirect.com.libproxy1.nus.edu.sg/science/article/B6WWK-4S1BVT4-7/2/0207748e31078d47895d75acb7d7d364} }

TY - GEN ID - inhibition L3 - citeulike-article-id:2705441 N2 - n vivo tumor cell migration through integrin-dependent pathways is key to the metastatic behavior of malignant cells. Using quantitative in vivo assays and intravital imaging, we assessed the impact of cell migration, regulated by the integrin-associated tetraspanin CD151, on spontaneous human tumor cell metastasis. We demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site. In vivo, this loss of migration is the result of enhanced tumor cell-matrix interactions, promoted by CD151, which prevent dissociation by individual cells and leads to a subsequent inhibition of invasion and intravasation at the site of the primary tumor. TI - The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151 KW - cancer KW - cd151 KW - metastasis UR - http://www.sciencedirect.com.libproxy1.nus.edu.sg/science/article/B6WWK-4S1BVT4-7/2/0207748e31078d47895d75acb7d7d364 ER -