The Global Circulation of Seasonal Influenza A (H3N2) Viruses Export

@article{russell_global_2008, abstract = {Antigenic and genetic analysis of the hemagglutinin of [{\\textasciitilde}]13,000 human influenza A (H3N2) viruses from six continents during 20022007 revealed that there was continuous circulation in east and Southeast Asia (E-SE Asia) via a region-wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year. Seed strains generally first reached Oceania, North America, and Europe, and later South America. This evidence suggests that once A (H3N2) viruses leave E-SE Asia, they are unlikely to contribute to long-term viral evolution. If the trends observed during this period are an accurate representation of overall patterns of spread, then the antigenic characteristics of A (H3N2) viruses outside E-SE Asia may be forecast each year based on surveillance within E-SE Asia, with consequent improvements to vaccine strain selection.}, author = {Russell, Colin A. and Jones, Terry C. and Barr, Ian G. and Cox, Nancy J. and Garten, Rebecca J. and Gregory, Vicky and Gust, Ian D. and Hampson, Alan W. and Hay, Alan J. and Hurt, Aeron C. and de Jong, Jan C. and Kelso, Anne and Klimov, Alexander I. and Kageyama, Tsutomu and Komadina, Naomi and Lapedes, Alan S. and Lin, Yi P. and Mosterin, Ana and Obuchi, Masatsugu and Odagiri, Takato and Osterhaus, Albert D. M. E. and Rimmelzwaan, Guus F. and Shaw, Michael W. and Skepner, Eugene and Stohr, Klaus and Tashiro, Masato and Fouchier, Ron A. M. and Smith, Derek J.}, citeulike-article-id = {2705504}, citeulike-linkout-0 = {http://www.sciencemag.org/cgi/content/abstract/320/5874/340}, citeulike-linkout-1 = {http://dx.doi.org/10.1126/science.1154137}, doi = {10.1126/science.1154137}, journal = {Science}, keywords = {epidemiology, influenza}, month = {April}, pages = {340--346}, posted-at = {2008-04-23 05:48:23}, priority = {0}, title = {The Global Circulation of Seasonal Influenza A (H3N2) Viruses}, url = {http://dx.doi.org/10.1126/science.1154137}, volume = {320}, year = {2008} }

TY - JOUR ID - russell_global_2008 L3 - citeulike-article-id:2705504 N2 - Antigenic and genetic analysis of the hemagglutinin of [{\\textasciitilde}]13,000 human influenza A (H3N2) viruses from six continents during 20022007 revealed that there was continuous circulation in east and Southeast Asia (E-SE Asia) via a region-wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year. Seed strains generally first reached Oceania, North America, and Europe, and later South America. This evidence suggests that once A (H3N2) viruses leave E-SE Asia, they are unlikely to contribute to long-term viral evolution. If the trends observed during this period are an accurate representation of overall patterns of spread, then the antigenic characteristics of A (H3N2) viruses outside E-SE Asia may be forecast each year based on surveillance within E-SE Asia, with consequent improvements to vaccine strain selection. JF - Science EP - 346 TI - The Global Circulation of Seasonal Influenza A (H3N2) Viruses VL - 320 SP - 340 KW - epidemiology KW - influenza AU - Russell, Colin AU - Jones, Terry AU - Barr, Ian AU - Cox, Nancy AU - Garten, Rebecca AU - Gregory, Vicky AU - Gust, Ian AU - Hampson, Alan AU - Hay, Alan AU - Hurt, Aeron AU - de Jong, Jan AU - Kelso, Anne AU - Klimov, Alexander AU - Kageyama, Tsutomu AU - Komadina, Naomi AU - Lapedes, Alan AU - Lin, Yi AU - Mosterin, Ana AU - Obuchi, Masatsugu AU - Odagiri, Takato AU - Osterhaus, Albert AU - Rimmelzwaan, Guus AU - Shaw, Michael AU - Skepner, Eugene AU - Stohr, Klaus AU - Tashiro, Masato AU - Fouchier, Ron AU - Smith, Derek PY - 2008/April// UR - http://dx.doi.org/10.1126/science.1154137 ER -