Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons Export

@article{citeulike:2773667, abstract = {Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change. 10.1126/science.1156093}, author = {Prahlad, Veena and Cornelius, Tyler and Morimoto, Richard I.}, citeulike-article-id = {2773667}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1156093}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/320/5877/811}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18467592}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18467592}, citeulike-linkout-4 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00031874}, day = {9}, doi = {10.1126/science.1156093}, journal = {Science}, keywords = {celegans, neuroscience, stress\_response}, month = {May}, number = {5877}, pages = {811--814}, posted-at = {2008-05-10 08:22:13}, priority = {2}, title = {Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons}, url = {http://dx.doi.org/10.1126/science.1156093}, volume = {320}, year = {2008} }

TY - JOUR ID - citeulike:2773667 L3 - citeulike-article-id:2773667 N2 - Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change. 10.1126/science.1156093 IS - 5877 JF - Science EP - 814 TI - Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons VL - 320 SP - 811 KW - celegans KW - neuroscience KW - stress_response AU - Prahlad, Veena AU - Cornelius, Tyler AU - Morimoto, Richard PY - 2008/05/09/ UR - http://dx.doi.org/10.1126/science.1156093 ER -