BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI Export

@article{citeulike:5869782, abstract = {▪ Abstract  The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between these compartments, reflecting the transport of newly synthesized proteins out of the ER and the retrieval of escaped ER residents and vesicle machinery. Anterograde and retrograde transport is mediated by distinct sets of cytosolic coat proteins, the COPII and COPI coats, respectively, which act on the membrane to capture cargo proteins into nascent vesicles. We review the mechanisms that govern coat recruitment to the membrane, cargo capture into a transport vesicle, and accurate delivery to the target organelle.}, author = {Lee, Marcus C. S. and Miller, Elizabeth A. and Goldberg, Jonathan and Orci, Lelio and Schekman, Randy}, citeulike-article-id = {5869782}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.cellbio.20.010403.105307}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.cellbio.20.010403.105307}, doi = {10.1146/annurev.cellbio.20.010403.105307}, journal = {Annual Review of Cell and Developmental Biology}, keywords = {bmb518, cop, endoplasmic\_reticulum, golgi, review, transport}, number = {1}, pages = {87--123}, posted-at = {2009-10-01 20:41:41}, priority = {2}, title = {BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI}, url = {http://dx.doi.org/10.1146/annurev.cellbio.20.010403.105307}, volume = {20}, year = {2004} }

TY - JOUR ID - citeulike:5869782 L3 - citeulike-article-id:5869782 N2 - ▪ Abstract  The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between these compartments, reflecting the transport of newly synthesized proteins out of the ER and the retrieval of escaped ER residents and vesicle machinery. Anterograde and retrograde transport is mediated by distinct sets of cytosolic coat proteins, the COPII and COPI coats, respectively, which act on the membrane to capture cargo proteins into nascent vesicles. We review the mechanisms that govern coat recruitment to the membrane, cargo capture into a transport vesicle, and accurate delivery to the target organelle. IS - 1 JF - Annual Review of Cell and Developmental Biology EP - 123 TI - BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI VL - 20 SP - 87 KW - bmb518 KW - cop KW - endoplasmic_reticulum KW - golgi KW - review KW - transport AU - Lee, Marcus AU - Miller, Elizabeth AU - Goldberg, Jonathan AU - Orci, Lelio AU - Schekman, Randy PY - 2004/// UR - http://dx.doi.org/10.1146/annurev.cellbio.20.010403.105307 ER -