New insights into cystic fibrosis: molecular switches that regulate CFTR Export

@article{citeulike:671890, abstract = {Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl--selective ion channel, is a prototypic member of the ATP-binding cassette transporter superfamily that is expressed in several organs. In these organs, CFTR assembles into large, dynamic macromolecular complexes that contain signalling molecules, kinases, transport proteins, PDZ-domain-containing proteins, myosin motors, Rab GTPases, and SNAREs. Understanding how these complexes regulate the intracellular trafficking and activity of CFTR provides a unique insight into the aetiology of cystic fibrosis and other diseases.}, author = {Guggino, William B. and Stanton, Bruce A.}, citeulike-article-id = {671890}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrm1949}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrm1949}, day = {01}, doi = {10.1038/nrm1949}, issn = {1471-0072}, journal = {Nature Reviews Molecular Cell Biology}, keywords = {bmb518, cftr, golgi, review, trafficking}, month = {June}, number = {6}, pages = {426--436}, posted-at = {2009-10-03 21:06:37}, priority = {2}, publisher = {Nature Publishing Group}, title = {New insights into cystic fibrosis: molecular switches that regulate CFTR}, url = {http://dx.doi.org/10.1038/nrm1949}, volume = {7}, year = {2006} }

TY - JOUR ID - citeulike:671890 L3 - citeulike-article-id:671890 N2 - Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl--selective ion channel, is a prototypic member of the ATP-binding cassette transporter superfamily that is expressed in several organs. In these organs, CFTR assembles into large, dynamic macromolecular complexes that contain signalling molecules, kinases, transport proteins, PDZ-domain-containing proteins, myosin motors, Rab GTPases, and SNAREs. Understanding how these complexes regulate the intracellular trafficking and activity of CFTR provides a unique insight into the aetiology of cystic fibrosis and other diseases. IS - 6 JF - Nature Reviews Molecular Cell Biology SN - 1471-0072 EP - 436 TI - New insights into cystic fibrosis: molecular switches that regulate CFTR PB - Nature Publishing Group VL - 7 SP - 426 KW - bmb518 KW - cftr KW - golgi KW - review KW - trafficking AU - Guggino, William AU - Stanton, Bruce PY - 2006/06/01/ UR - http://dx.doi.org/10.1038/nrm1949 ER -