Non|[ndash]|coding RNA genes and the modern RNA world Export

@article{citeulike:118694, abstract = {Non-coding RNA (ncRNA) genes produce functional RNA molecules rather than encoding proteins. However, almost all means of gene identification assume that genes encode proteins, so even in the era of complete genome sequences, ncRNA genes have been effectively invisible. Recently, several different systematic screens have identified a surprisingly large number of new ncRNA genes. Non-coding RNAs seem to be particularly abundant in roles that require highly specific nucleic acid recognition without complex catalysis, such as in directing post-transcriptional regulation of gene expression or in guiding RNA modifications.}, address = {Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA. eddy@genetics.wustl.edu}, author = {Eddy, Sean R.}, citeulike-article-id = {118694}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/35103511}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg1201-919a}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11733745}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11733745}, day = {01}, doi = {10.1038/35103511}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, keywords = {ncrna}, month = {December}, number = {12}, pages = {919--929}, posted-at = {2009-11-01 22:41:13}, priority = {2}, publisher = {Nature Publishing Group}, title = {Non|[ndash]|coding RNA genes and the modern RNA world }, url = {http://dx.doi.org/10.1038/35103511}, volume = {2}, year = {2001} }

TY - JOUR ID - citeulike:118694 L3 - citeulike-article-id:118694 N2 - Non-coding RNA (ncRNA) genes produce functional RNA molecules rather than encoding proteins. However, almost all means of gene identification assume that genes encode proteins, so even in the era of complete genome sequences, ncRNA genes have been effectively invisible. Recently, several different systematic screens have identified a surprisingly large number of new ncRNA genes. Non-coding RNAs seem to be particularly abundant in roles that require highly specific nucleic acid recognition without complex catalysis, such as in directing post-transcriptional regulation of gene expression or in guiding RNA modifications. IS - 12 JF - Nature Reviews Genetics SN - 1471-0056 AD - Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA. eddy@genetics.wustl.edu EP - 929 TI - Non|[ndash]|coding RNA genes and the modern RNA world PB - Nature Publishing Group VL - 2 SP - 919 KW - ncrna AU - Eddy, Sean PY - 2001/12/01/ UR - http://dx.doi.org/10.1038/35103511 ER -