Hematopoietic cytokines Export

@article{citeulike:2236251, abstract = {The production of hematopoietic cells is under the tight control of a group of hematopoietic cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic domains contain specialized regions initiating the various responsessurvival, proliferation, differentiation commitment, maturation, and functional activation. Individual cytokines can be lineage specific or can regulate cells in multiple lineages, and for some cell types, such as stem cells or megakaryocyte progenitors, the simultaneous action of multiple cytokines is required for proliferative responses. The same cytokines control basal and emergency hematopoietic cell proliferation. Three cytokines, erythropoietin, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor, have now been in routine clinical use to stimulate cell production and in total have been used in the management of many millions of patients. In this little review, discussion will be restricted to those cytokines well established as influencing the production of hematopoietic cells and will exclude newer candidate regulators and those active on lymphoid cells. As requested, this account will describe the cytokines in a historical manner, using a sequential format of discovery, understanding, validation, and puzzlement, a sequence that reflects the evolving views on these cytokines over the past 50 years. 10.1182/blood-2007-03-079681}, author = {Metcalf, Donald}, citeulike-article-id = {2236251}, citeulike-linkout-0 = {http://dx.doi.org/10.1182/blood-2007-03-079681}, citeulike-linkout-1 = {http://bloodjournal.hematologylibrary.org/cgi/content/abstract/111/2/485}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18182579}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18182579}, day = {15}, doi = {10.1182/blood-2007-03-079681}, journal = {Blood}, keywords = {biology, blood-stage, human}, month = {January}, number = {2}, pages = {485--491}, posted-at = {2009-01-10 15:13:48}, priority = {2}, title = {Hematopoietic cytokines}, url = {http://dx.doi.org/10.1182/blood-2007-03-079681}, volume = {111}, year = {2008} }

TY - JOUR ID - citeulike:2236251 L3 - citeulike-article-id:2236251 N2 - The production of hematopoietic cells is under the tight control of a group of hematopoietic cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic domains contain specialized regions initiating the various responsessurvival, proliferation, differentiation commitment, maturation, and functional activation. Individual cytokines can be lineage specific or can regulate cells in multiple lineages, and for some cell types, such as stem cells or megakaryocyte progenitors, the simultaneous action of multiple cytokines is required for proliferative responses. The same cytokines control basal and emergency hematopoietic cell proliferation. Three cytokines, erythropoietin, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor, have now been in routine clinical use to stimulate cell production and in total have been used in the management of many millions of patients. In this little review, discussion will be restricted to those cytokines well established as influencing the production of hematopoietic cells and will exclude newer candidate regulators and those active on lymphoid cells. As requested, this account will describe the cytokines in a historical manner, using a sequential format of discovery, understanding, validation, and puzzlement, a sequence that reflects the evolving views on these cytokines over the past 50 years. 10.1182/blood-2007-03-079681 IS - 2 JF - Blood EP - 491 TI - Hematopoietic cytokines VL - 111 SP - 485 KW - biology KW - blood-stage KW - human AU - Metcalf, Donald PY - 2008/01/15/ UR - http://dx.doi.org/10.1182/blood-2007-03-079681 ER -