Host cell traversal is important for progression of the malaria parasite through the dermis to the liver. Export

@article{citeulike:2570905, abstract = {The malaria sporozoite, the parasite stage transmitted by the mosquito, is delivered into the dermis and differentiates in the liver. Motile sporozoites can invade host cells by disrupting their plasma membrane and migrating through them (termed cell traversal), or by forming a parasite-cell junction and settling inside an intracellular vacuole (termed cell infection). Traversal of liver cells, observed for sporozoites in vivo, is thought to activate the sporozoite for infection of a final hepatocyte. Here, using Plasmodium berghei, we show that cell traversal is important in the host dermis for preventing sporozoite destruction by phagocytes and arrest by nonphagocytic cells. We also show that cell infection is a pathway that is masked, rather than activated, by cell traversal. We propose that the cell traversal activity of the sporozoite must be turned on for progression to the liver parenchyma, where it must be switched off for infection of a final hepatocyte.}, address = {Unit\'{e} de Biologie et G\'{e}n\'{e}tique du Paludisme, Institut Pasteur, 28 Rue du Dr Roux, 75724 Paris cedex 15, France.}, author = {Amino, R. and Giovannini, D. and Thiberge, S. and Gueirard, P. and Boisson, B. and Dubremetz, J. F. and Pr\'{e}vost, M. C. and Ishino, T. and Yuda, M. and M\'{e}nard, R.}, citeulike-article-id = {2570905}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.chom.2007.12.007}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18312843}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18312843}, day = {14}, doi = {10.1016/j.chom.2007.12.007}, issn = {1934-6069}, journal = {Cell Host Microbe}, keywords = {journal-club, malaria}, month = {February}, number = {2}, pages = {88--96}, posted-at = {2008-03-22 01:32:11}, priority = {2}, title = {Host cell traversal is important for progression of the malaria parasite through the dermis to the liver.}, url = {http://dx.doi.org/10.1016/j.chom.2007.12.007}, volume = {3}, year = {2008} }

TY - JOUR ID - citeulike:2570905 L3 - citeulike-article-id:2570905 N2 - The malaria sporozoite, the parasite stage transmitted by the mosquito, is delivered into the dermis and differentiates in the liver. Motile sporozoites can invade host cells by disrupting their plasma membrane and migrating through them (termed cell traversal), or by forming a parasite-cell junction and settling inside an intracellular vacuole (termed cell infection). Traversal of liver cells, observed for sporozoites in vivo, is thought to activate the sporozoite for infection of a final hepatocyte. Here, using Plasmodium berghei, we show that cell traversal is important in the host dermis for preventing sporozoite destruction by phagocytes and arrest by nonphagocytic cells. We also show that cell infection is a pathway that is masked, rather than activated, by cell traversal. We propose that the cell traversal activity of the sporozoite must be turned on for progression to the liver parenchyma, where it must be switched off for infection of a final hepatocyte. IS - 2 JF - Cell Host Microbe SN - 1934-6069 AD - Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 28 Rue du Dr Roux, 75724 Paris cedex 15, France. EP - 96 TI - Host cell traversal is important for progression of the malaria parasite through the dermis to the liver. VL - 3 SP - 88 KW - journal-club KW - malaria AU - Amino, R AU - Giovannini, D AU - Thiberge, S AU - Gueirard, P AU - Boisson, B AU - Dubremetz, JF AU - Prévost, MC AU - Ishino, T AU - Yuda, M AU - Ménard, R PY - 2008/02/14/ UR - http://dx.doi.org/10.1016/j.chom.2007.12.007 ER -