The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria Export

@article{citeulike:3075862, abstract = {BACKGROUND:Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. METHODS:Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion.RESULTS:A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (+/-SD) of -0.69 (+/-1.3) for children under the age of 5 (n=1,440 measurements from 449 patients). CONCLUSIONS:Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid.}, author = {Lee, Sue and Stepniewska, Kasia and Anstey, Nicholas and Ashley, Elizabeth and Barnes, Karen and Binh, Tran Q. and D'Alessandro, Umberto and Day, Nicholas and de Vries, Peter and Dorsey, Grant and Guthmann, Jean P. and Mayxay, Mayfong and Newton, Paul and Nosten, Francois and Olliaro, Piero and Osario, Lyda and Pinoges, Loretxu and Price, Ric and Rowland, Mark and Smithuis, Frank and Taylor, Robert and White, Nicholas}, citeulike-article-id = {3075862}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1475-2875-7-149}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18673575}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18673575}, citeulike-linkout-3 = {http://www.malariajournal.com/content/7/1/149}, doi = {10.1186/1475-2875-7-149}, journal = {Malaria Journal}, keywords = {clinical-associations, malaria}, number = {1}, posted-at = {2008-08-02 13:56:56}, priority = {2}, title = {The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria}, url = {http://dx.doi.org/10.1186/1475-2875-7-149}, volume = {7}, year = {2008} }

TY - JOUR ID - citeulike:3075862 L3 - citeulike-article-id:3075862 N2 - BACKGROUND:Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. METHODS:Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion.RESULTS:A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (+/-SD) of -0.69 (+/-1.3) for children under the age of 5 (n=1,440 measurements from 449 patients). CONCLUSIONS:Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid. IS - 1 JF - Malaria Journal TI - The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria VL - 7 KW - clinical-associations KW - malaria AU - Lee, Sue AU - Stepniewska, Kasia AU - Anstey, Nicholas AU - Ashley, Elizabeth AU - Barnes, Karen AU - Binh, Tran AU - D'Alessandro, Umberto AU - Day, Nicholas AU - de Vries, Peter AU - Dorsey, Grant AU - Guthmann, Jean AU - Mayxay, Mayfong AU - Newton, Paul AU - Nosten, Francois AU - Olliaro, Piero AU - Osario, Lyda AU - Pinoges, Loretxu AU - Price, Ric AU - Rowland, Mark AU - Smithuis, Frank AU - Taylor, Robert AU - White, Nicholas PY - 2008/// UR - http://dx.doi.org/10.1186/1475-2875-7-149 ER -