The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Export

@article{citeulike:3420327, abstract = {Plasmodium vivax causes over 100 million clinical infections each year. Primarily because of the lack of a suitable culture system, our understanding of the biology of this parasite lags significantly behind that of the more deadly species P. falciparum. Here, we present the complete transcriptional profile throughout the 48-h intraerythrocytic cycle of three distinct P. vivax isolates. This approach identifies strain specific patterns of expression for subsets of genes predicted to encode proteins associated with virulence and host pathogen interactions. Comparison to P. falciparum revealed significant differences in the expression of genes involved in crucial cellular functions that underpin the biological differences between the two parasite species. These data provide insights into the biology of P. vivax and constitute an important resource for the development of therapeutic approaches.}, author = {Bozdech, Zbynek and Mok, Sachel and Hu, Guangan and Imwong, Mallika and Jaidee, Anchalee and Russell, Bruce and Ginsburg, Hagai and Nosten, Francois and Day, Nicholas P J P. and White, Nicholas J J. and Carlton, Jane M M. and Preiser, Peter R R.}, citeulike-article-id = {3420327}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0807404105}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18852452}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18852452}, day = {13}, doi = {10.1073/pnas.0807404105}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {malaria, microarray}, month = {October}, posted-at = {2008-10-16 13:23:13}, priority = {2}, title = {The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites.}, url = {http://dx.doi.org/10.1073/pnas.0807404105}, year = {2008} }

TY - JOUR ID - citeulike:3420327 L3 - citeulike-article-id:3420327 N2 - Plasmodium vivax causes over 100 million clinical infections each year. Primarily because of the lack of a suitable culture system, our understanding of the biology of this parasite lags significantly behind that of the more deadly species P. falciparum. Here, we present the complete transcriptional profile throughout the 48-h intraerythrocytic cycle of three distinct P. vivax isolates. This approach identifies strain specific patterns of expression for subsets of genes predicted to encode proteins associated with virulence and host pathogen interactions. Comparison to P. falciparum revealed significant differences in the expression of genes involved in crucial cellular functions that underpin the biological differences between the two parasite species. These data provide insights into the biology of P. vivax and constitute an important resource for the development of therapeutic approaches. JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 TI - The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. KW - malaria KW - microarray AU - Bozdech, Zbynek AU - Mok, Sachel AU - Hu, Guangan AU - Imwong, Mallika AU - Jaidee, Anchalee AU - Russell, Bruce AU - Ginsburg, Hagai AU - Nosten, Francois AU - Day, Nicholas P J AU - White, Nicholas J AU - Carlton, Jane M AU - Preiser, Peter R PY - 2008/10/13/ UR - http://dx.doi.org/10.1073/pnas.0807404105 ER -