Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity Export

@article{citeulike:3740164, abstract = {BACKGROUND:The aim of this study was to identify and compare factors associated with P.falciparum gametocyte carriage in three regions of differing malaria endemicity. METHODS:Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials which investigated gametocyte carriage after different antimalarial drug treatments.RESULTS:Gametocytaemia was detected during the observation period in 12\% of patients (931 out of 7548) in Thailand, 34\% (683 out of 2020) in The Gambia, and 31\% (430 out of 1400) in Tanzania (p<0.001). Approximately one third (33\%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day1): 35\% (318 / 931) in Thailand, 37\% (250 / 683) in The Gambia, 26\% (112 / 430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93\% in Thailand, 70\% in Tanzania and 78\% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine-pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (P<0.001). The duration of gametocyte carriage was shorter in Thailand by 86\% and Tanzania by 65\% than in The Gambia. Gametocyte carriage was 27\% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27\% in Thailand and by 71\% in Tanzania and The Gambia.CONCLUSIONS:This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between centres with different levels of malaria transmission suggests that drug interventions to prevent transmission will have different effects in different places.}, author = {Stepniewska, Kasia and Price, Ric and Sutherland, Colin and Drakeley, Chris and von Seidlein, Lorenz and Nosten, Francois and White, Nicholas}, citeulike-article-id = {3740164}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1475-2875-7-249}, doi = {10.1186/1475-2875-7-249}, issn = {1475-2875}, journal = {Malaria Journal}, keywords = {malaria}, number = {1}, posted-at = {2008-12-03 13:15:45}, priority = {2}, title = {Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity}, url = {http://dx.doi.org/10.1186/1475-2875-7-249}, volume = {7}, year = {2008} }

TY - JOUR ID - citeulike:3740164 L3 - citeulike-article-id:3740164 N2 - BACKGROUND:The aim of this study was to identify and compare factors associated with P.falciparum gametocyte carriage in three regions of differing malaria endemicity. METHODS:Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials which investigated gametocyte carriage after different antimalarial drug treatments.RESULTS:Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p<0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day1): 35% (318 / 931) in Thailand, 37% (250 / 683) in The Gambia, 26% (112 / 430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine-pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (P<0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia.CONCLUSIONS:This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between centres with different levels of malaria transmission suggests that drug interventions to prevent transmission will have different effects in different places. IS - 1 JF - Malaria Journal SN - 1475-2875 TI - Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity VL - 7 KW - malaria AU - Stepniewska, Kasia AU - Price, Ric AU - Sutherland, Colin AU - Drakeley, Chris AU - von Seidlein, Lorenz AU - Nosten, Francois AU - White, Nicholas PY - 2008/// UR - http://dx.doi.org/10.1186/1475-2875-7-249 ER -