Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids. Export

@article{citeulike:3986871, abstract = {The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as "eat me" signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity.}, author = {Sturm, Angelika and Amino, Rogerio and van de Sand, Claudia and Regen, Tommy and Retzlaff, Silke and Rennenberg, Annika and Krueger, Andreas and Pollok, J\"{o}rg-Matthias M. and Menard, Robert and Heussler, Volker T.}, citeulike-article-id = {3986871}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1129720}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/313/5791/1287}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16888102}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16888102}, day = {1}, doi = {10.1126/science.1129720}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {liver-stage, malaria}, month = {September}, number = {5791}, pages = {1287--1290}, posted-at = {2009-01-31 06:01:00}, priority = {2}, title = {Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids.}, url = {http://dx.doi.org/10.1126/science.1129720}, volume = {313}, year = {2006} }

TY - JOUR ID - citeulike:3986871 L3 - citeulike-article-id:3986871 N2 - The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as "eat me" signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity. IS - 5791 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 1290 TI - Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids. VL - 313 SP - 1287 KW - liver-stage KW - malaria AU - Sturm, Angelika AU - Amino, Rogerio AU - van de Sand, Claudia AU - Regen, Tommy AU - Retzlaff, Silke AU - Rennenberg, Annika AU - Krueger, Andreas AU - Pollok, Jörg-Matthias AU - Menard, Robert AU - Heussler, Volker PY - 2006/09/01/ UR - http://dx.doi.org/10.1126/science.1129720 ER -