Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding. Export

@article{citeulike:4052134, abstract = {To clarify the role of CD36 as a TSP receptor and to investigate the mechanisms of the TSP-CD36 interaction, transfection studies were performed using CD36-cDNA in a CDM8 plasmid. Jurkat cells transfected with CD36 cDNA express an 88kD membrane surface protein and acquire the ability to bind thrombospondin. The TSP amino acid sequence, CSVTCG, mediates the interaction of thrombospondin with CD36. CD36 transfectants but not control transfectants bind radiolabeled tyrosinated peptide (YCSVTCG). The hexapeptide inhibits thrombospondin expression on activated human platelets and results in diminished platelet aggregation. CSVTCG-albumin conjugates support CD36-dependent adhesion of tumor cells. We conclude that the CSVTCG repeat sequence is a crucial determinant of CD36 thrombospondin binding.}, author = {Asch, A. S. and Silbiger, S. and Heimer, E. and Nachman, R. L.}, citeulike-article-id = {4052134}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/1371676}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=1371676}, day = {14}, issn = {0006-291X}, journal = {Biochemical and biophysical research communications}, keywords = {cd36, receptor-ligand}, month = {February}, number = {3}, pages = {1208--1217}, posted-at = {2009-02-14 18:35:18}, priority = {2}, title = {Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1371676}, volume = {182}, year = {1992} }

TY - JOUR ID - citeulike:4052134 L3 - citeulike-article-id:4052134 N2 - To clarify the role of CD36 as a TSP receptor and to investigate the mechanisms of the TSP-CD36 interaction, transfection studies were performed using CD36-cDNA in a CDM8 plasmid. Jurkat cells transfected with CD36 cDNA express an 88kD membrane surface protein and acquire the ability to bind thrombospondin. The TSP amino acid sequence, CSVTCG, mediates the interaction of thrombospondin with CD36. CD36 transfectants but not control transfectants bind radiolabeled tyrosinated peptide (YCSVTCG). The hexapeptide inhibits thrombospondin expression on activated human platelets and results in diminished platelet aggregation. CSVTCG-albumin conjugates support CD36-dependent adhesion of tumor cells. We conclude that the CSVTCG repeat sequence is a crucial determinant of CD36 thrombospondin binding. IS - 3 JF - Biochemical and biophysical research communications SN - 0006-291X EP - 1217 TI - Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding. VL - 182 SP - 1208 KW - cd36 KW - receptor-ligand AU - Asch, AS AU - Silbiger, S AU - Heimer, E AU - Nachman, RL PY - 1992/02/14/ UR - http://view.ncbi.nlm.nih.gov/pubmed/1371676 ER -