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Artificial, Parallel, Left-Handed DNA Helices

by: Cheng Tian, Chuan Zhang, Xiang Li, Yingmei Li, Guansong Wang, Chengde Mao
J. Am. Chem. Soc. In Journal of the American Chemical Society, Vol. 134, No. 50. (10 December 2012), pp. 20273-20275, doi:10.1021/ja309908s  Key: citeulike:11840741

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Abstract

This communication reports an engineered DNA architecture. It contains multiple domains of half-turn-long, standard B-DNA duplexes. While each helical domain is right-handed and its two component strands are antiparallel, the global architecture is left-handed and the two component DNA strands are oriented parallel to each other.


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