Matrix Gla Protein Polymorphisms are Associated with Coronary Artery Calcification in Men Export

@article{citeulike:5883387, abstract = {Matrix Gla protein (MGP) is a key regulator of vascular calcification. Genetic variation at the <i>MGP</i> locus could modulate the development of coronary artery calcification (CAC). Our aim was to examine the cross-sectional association between <i>MGP</i> single nucleotide polymorphisms (SNPs) [rs1800802 (T-138C), rs1800801 (G-7A), and rs4236 (Ala102Thr)] and CAC. CAC was measured by multidetector computed tomography (MDCT), in older men and women of European descent, (<i>n</i>=386; 60 to 80 y of age). Serum MGP was measured by radioimmunoassay. Linear, Tobit and Ordinal regression analyses all revealed that in men, homozygous carriers of the minor allele of <i>rs1800802</i>, <i>rs1800801</i>, or <i>rs4236</i> (minor allele frequency: 21, 38, and 40\%, respectively) were associated with a decreased quantity of CAC, relative to major allele carriers. This association was not found in women. Although genetic variation in <i>MGP</i> was associated with serum MGP concentrations, there were no associations between serum MGP and CAC. The results of this study suggest a role for <i>MGP</i> genetic variants in coronary atherosclerosis among men that is not reflected in serum MGP concentrations.}, author = {Crosier, Michael D. and Booth, Sarah L. and Peter, Inga and Dawson-Hughes, Bess and Price, Paul A. and O'Donnell, Christopher J. and Hoffmann, Udo and Williamson, Matthew K. and Ordovas, Jose M.}, citeulike-article-id = {5883387}, citeulike-linkout-0 = {http://dx.doi.org/10.3177/jnsv.55.59}, citeulike-linkout-1 = {http://www.jstage.jst.go.jp/article/jnsv/55/1/55_59/_article/-char/ja/}, citeulike-linkout-2 = {http://www.jstage.jst.go.jp/article/jnsv/55/1/55_59/_article/}, doi = {10.3177/jnsv.55.59}, journal = {Journal of Nutritional Science and Vitaminology}, keywords = {arthery, clacification, coronary, gla, protein}, number = {1}, pages = {59--65}, posted-at = {2009-10-04 01:11:22}, priority = {5}, title = {Matrix Gla Protein Polymorphisms are Associated with Coronary Artery Calcification in Men}, url = {http://dx.doi.org/10.3177/jnsv.55.59}, volume = {55}, year = {2009} }

TY - JOUR ID - citeulike:5883387 L3 - citeulike-article-id:5883387 N2 - Matrix Gla protein (MGP) is a key regulator of vascular calcification. Genetic variation at the <i>MGP</i> locus could modulate the development of coronary artery calcification (CAC). Our aim was to examine the cross-sectional association between <i>MGP</i> single nucleotide polymorphisms (SNPs) [rs1800802 (T-138C), rs1800801 (G-7A), and rs4236 (Ala102Thr)] and CAC. CAC was measured by multidetector computed tomography (MDCT), in older men and women of European descent, (<i>n</i>=386; 60 to 80 y of age). Serum MGP was measured by radioimmunoassay. Linear, Tobit and Ordinal regression analyses all revealed that in men, homozygous carriers of the minor allele of <i>rs1800802</i>, <i>rs1800801</i>, or <i>rs4236</i> (minor allele frequency: 21, 38, and 40%, respectively) were associated with a decreased quantity of CAC, relative to major allele carriers. This association was not found in women. Although genetic variation in <i>MGP</i> was associated with serum MGP concentrations, there were no associations between serum MGP and CAC. The results of this study suggest a role for <i>MGP</i> genetic variants in coronary atherosclerosis among men that is not reflected in serum MGP concentrations. IS - 1 JF - Journal of Nutritional Science and Vitaminology EP - 65 TI - Matrix Gla Protein Polymorphisms are Associated with Coronary Artery Calcification in Men VL - 55 SP - 59 KW - arthery KW - clacification KW - coronary KW - gla KW - protein AU - Crosier, Michael AU - Booth, Sarah AU - Peter, Inga AU - Dawson-Hughes, Bess AU - Price, Paul AU - O'Donnell, Christopher AU - Hoffmann, Udo AU - Williamson, Matthew AU - Ordovas, Jose PY - 2009/// UR - http://dx.doi.org/10.3177/jnsv.55.59 ER -