Increased Gastrointestinal Permeability and Gut Inflammation in Children with Functional Abdominal Pain and Irritable Bowel Syndrome. Export

@article{citeulike:2901683, abstract = {OBJECTIVES: To determine gastrointestinal (GI) permeability and fecal calprotectin concentration in children 7 to 10 years of age with functional abdominal pain and irritable bowel syndrome (FAP/IBS) versus control subjects and ascertain potential relationships with pain symptoms and stooling. STUDY DESIGN: GI permeability and fecal calprotectin concentration were measured. Children kept a 2-week diary of pain episodes and stooling pattern. RESULTS: Proximal GI permeability was greater in the FAP/IBS group (n = 93) compared with control subjects (n = 52) (0.59 +/- 0.50 vs 0.36 +/- 0.26, respectively; mean +/- SD; P < .001) as was colonic permeability (1.01 +/- 0.67 vs 0.81 +/- 0.43, respectively; P < .05). Gastric and small intestinal permeability were similar. Fecal calprotectin concentration was greater in children with FAP/IBS compared with control children (65.5 +/- 75.4 mug/g stool vs 43.2 +/- 39.4, respectively; P < .01). Fecal calprotectin concentration correlated with pain interference with activities (P = .01, r(2) = 0.36). There was no correlation between GI permeability and pain related symptoms. Neither permeability nor fecal calprotectin correlated with stool form. CONCLUSIONS: Children with FAP/IBS have evidence of increased GI permeability and low-grade GI inflammation, with the latter relating to the degree to which pain interferes with activities.}, address = {Department of Pediatrics, Houston, TX; Baylor College of Medicine, Houston, TX; Texas Children's HospitalHouston, TX; the Children's Nutrition Research Center, Wilmington, DE.}, author = {Shulman, Robert J J. and Eakin, Michelle N N. and Czyzewski, Danita I I. and Jarrett, Monica and Ou, Ching-Nan N.}, citeulike-article-id = {2901683}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jpeds.2008.04.062}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18538790}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18538790}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6WKR-4SPSHN1-3/1/4f83bb7be7db3ce6f2c9f03c62baf90e}, day = {6}, doi = {10.1016/j.jpeds.2008.04.062}, issn = {1097-6833}, journal = {The Journal of pediatrics}, keywords = {irritable, pain, permeability}, month = {June}, posted-at = {2008-06-19 22:25:26}, priority = {4}, title = {Increased Gastrointestinal Permeability and Gut Inflammation in Children with Functional Abdominal Pain and Irritable Bowel Syndrome.}, url = {http://dx.doi.org/10.1016/j.jpeds.2008.04.062}, year = {2008} }

TY - JOUR ID - citeulike:2901683 L3 - citeulike-article-id:2901683 N2 - OBJECTIVES: To determine gastrointestinal (GI) permeability and fecal calprotectin concentration in children 7 to 10 years of age with functional abdominal pain and irritable bowel syndrome (FAP/IBS) versus control subjects and ascertain potential relationships with pain symptoms and stooling. STUDY DESIGN: GI permeability and fecal calprotectin concentration were measured. Children kept a 2-week diary of pain episodes and stooling pattern. RESULTS: Proximal GI permeability was greater in the FAP/IBS group (n = 93) compared with control subjects (n = 52) (0.59 +/- 0.50 vs 0.36 +/- 0.26, respectively; mean +/- SD; P < .001) as was colonic permeability (1.01 +/- 0.67 vs 0.81 +/- 0.43, respectively; P < .05). Gastric and small intestinal permeability were similar. Fecal calprotectin concentration was greater in children with FAP/IBS compared with control children (65.5 +/- 75.4 mug/g stool vs 43.2 +/- 39.4, respectively; P < .01). Fecal calprotectin concentration correlated with pain interference with activities (P = .01, r(2) = 0.36). There was no correlation between GI permeability and pain related symptoms. Neither permeability nor fecal calprotectin correlated with stool form. CONCLUSIONS: Children with FAP/IBS have evidence of increased GI permeability and low-grade GI inflammation, with the latter relating to the degree to which pain interferes with activities. JF - The Journal of pediatrics SN - 1097-6833 AD - Department of Pediatrics, Houston, TX; Baylor College of Medicine, Houston, TX; Texas Children's HospitalHouston, TX; the Children's Nutrition Research Center, Wilmington, DE. TI - Increased Gastrointestinal Permeability and Gut Inflammation in Children with Functional Abdominal Pain and Irritable Bowel Syndrome. KW - irritable KW - pain KW - permeability AU - Shulman, Robert J AU - Eakin, Michelle N AU - Czyzewski, Danita I AU - Jarrett, Monica AU - Ou, Ching-Nan PY - 2008/06/06/ UR - http://dx.doi.org/10.1016/j.jpeds.2008.04.062 ER -