Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory study. Export

@article{citeulike:3362883, abstract = {OBJECTIVE: To assess the potential efficacy, tolerability, and safety of citalopram in the treatment of functional pediatric recurrent abdominal pain and comorbid internalizing disorders. METHOD: Twenty-five clinically referred children and adolescents with recurrent abdominal pain aged 7 to 18 years, inclusive, participated in a 12-week, flexible-dose, open-label trial of citalopram. Primary outcome measure was the Clinical Global Impression Scale-Improvement, with responders defined by ratings of 1 (very much improved) or 2 (much improved). Secondary measures included self- and parent reports of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment. Side effects were assessed using a standardized checklist. Data were analyzed using an intent-to-treat format and the last observation carried forward procedure. RESULTS: Twenty-one subjects (84\%) were classified as responders (Clinical Global Impression Scale-Improvement score < or =2). Citalopram was generally well tolerated. Four subjects withdrew prematurely, one due to reported visual side effects. Ratings of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment all improved significantly over the course of the study compared with baseline. CONCLUSIONS: Citalopram is a promising treatment for functional pediatric recurrent abdominal pain and deserves additional study with a randomized, placebo-controlled clinical trial.}, author = {Campo, J. V. and Perel, J. and Lucas, A. and Bridge, J. and Ehmann, M. and Kalas, C. and Monk, K. and Axelson, D. and Birmaher, B. and Ryan, N. and Di Lorenzo, C. and Brent, D. A.}, citeulike-article-id = {3362883}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15381890}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15381890}, issn = {0890-8567}, journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, keywords = {abdominal\_pain, citalopram, gastrointesinal, pain, serotonin}, month = {October}, number = {10}, pages = {1234--1242}, posted-at = {2008-10-01 14:25:17}, priority = {3}, title = {Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory study.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15381890}, volume = {43}, year = {2004} }

TY - JOUR ID - citeulike:3362883 L3 - citeulike-article-id:3362883 N2 - OBJECTIVE: To assess the potential efficacy, tolerability, and safety of citalopram in the treatment of functional pediatric recurrent abdominal pain and comorbid internalizing disorders. METHOD: Twenty-five clinically referred children and adolescents with recurrent abdominal pain aged 7 to 18 years, inclusive, participated in a 12-week, flexible-dose, open-label trial of citalopram. Primary outcome measure was the Clinical Global Impression Scale-Improvement, with responders defined by ratings of 1 (very much improved) or 2 (much improved). Secondary measures included self- and parent reports of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment. Side effects were assessed using a standardized checklist. Data were analyzed using an intent-to-treat format and the last observation carried forward procedure. RESULTS: Twenty-one subjects (84%) were classified as responders (Clinical Global Impression Scale-Improvement score < or =2). Citalopram was generally well tolerated. Four subjects withdrew prematurely, one due to reported visual side effects. Ratings of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment all improved significantly over the course of the study compared with baseline. CONCLUSIONS: Citalopram is a promising treatment for functional pediatric recurrent abdominal pain and deserves additional study with a randomized, placebo-controlled clinical trial. IS - 10 JF - Journal of the American Academy of Child and Adolescent Psychiatry SN - 0890-8567 EP - 1242 TI - Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory study. VL - 43 SP - 1234 KW - abdominal_pain KW - citalopram KW - gastrointesinal KW - pain KW - serotonin AU - Campo, JV AU - Perel, J AU - Lucas, A AU - Bridge, J AU - Ehmann, M AU - Kalas, C AU - Monk, K AU - Axelson, D AU - Birmaher, B AU - Ryan, N AU - Di Lorenzo, C AU - Brent, DA PY - 2004/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/15381890 ER -