Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3. Export

@article{citeulike:3441628, abstract = {Glucose tolerance progressively declines with age in humans and is often accompanied by insulin resistance and a high prevalence of type 2 diabetes. Little is known about the mechanism underlying the age-related changes in glucose metabolism. Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally expressed in adipose cells. ASIC3(-/-) mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity. Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25-27 weeks) ASIC3(+/+) mice. Moreover, the enhanced glucose control in aging ASIC3(-/-) mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues. Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance.}, author = {Huang, S. J. and Yang, W. S. and Lin, Y. W. and Wang, H. C. and Chen, C. C.}, citeulike-article-id = {3441628}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbrc.2008.04.147}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18466760}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18466760}, day = {11}, doi = {10.1016/j.bbrc.2008.04.147}, issn = {1090-2104}, journal = {Biochemical and biophysical research communications}, keywords = {age-dependant\_glucose\_intolerance, asic3, insulin\_sensitivity}, month = {July}, number = {4}, pages = {729--734}, posted-at = {2008-10-23 03:01:02}, priority = {3}, title = {Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3.}, url = {http://dx.doi.org/10.1016/j.bbrc.2008.04.147}, volume = {371}, year = {2008} }

TY - JOUR ID - citeulike:3441628 L3 - citeulike-article-id:3441628 N2 - Glucose tolerance progressively declines with age in humans and is often accompanied by insulin resistance and a high prevalence of type 2 diabetes. Little is known about the mechanism underlying the age-related changes in glucose metabolism. Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally expressed in adipose cells. ASIC3(-/-) mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity. Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25-27 weeks) ASIC3(+/+) mice. Moreover, the enhanced glucose control in aging ASIC3(-/-) mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues. Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance. IS - 4 JF - Biochemical and biophysical research communications SN - 1090-2104 EP - 734 TI - Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3. VL - 371 SP - 729 KW - age-dependant_glucose_intolerance KW - asic3 KW - insulin_sensitivity AU - Huang, SJ AU - Yang, WS AU - Lin, YW AU - Wang, HC AU - Chen, CC PY - 2008/07/11/ UR - http://dx.doi.org/10.1016/j.bbrc.2008.04.147 ER -